courtesy : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979411/

Abstract
Multimodal treatment concepts including liver transplantation for hepatocellular carcinoma (HCC), extended resection methods and neoadjuvant chemotherapy for colorectal liver metastasis significantly improve patients’ outcome. However, surgery-induced hepatic ischemia-reperfusion injury (IRI) and chemotherapy-associated hepatotoxicity result in hepatocellular damage and compromised liver function. Activation of common key pathways in ischemic liver and hepatotoxic injury results in oxidative stress, inflammatory responses and apoptosis causing organ damage. Controlling liver damage before and during surgery is essential for the postoperative outcome. Nigella sativa has a long tradition as a natural remedy. In the essential oil, Thymoquinone (TQ) was identified as the main component and responsible for most of the therapeutic effects. Therefore, this systematic review aimed to summarize the hepatoprotective effects of TQ and its potential suitability to improve surgical outcome by reducing surgical ischemic injury and hepatotoxicity of neoadjuvant chemotherapy. The key findings can be summarized as TQ having strong antioxidant, anti-inflammatory, antifibrotic, anti-/proapoptotic and anticarcinogenic effects. Almost no side effects were reported irrespective of a large dose range, suggesting a wide therapeutic window. These results give rise to the expectation that TQ could evolve to a novel powerful drug to reduce hepatic injury.

Keywords: Nigella sativa, Thymoquinone, natural remedy, liver, ischemia/reperfusion injury, hepatotoxicity, chemotherapy, hepatic injury

Hi,
I hope everyone is doing good.
I'm Beta thalassemia, on regular blood transfusion. Mother of 6yr child. Working professional. moderate activity level, Tired. Gallbladder removed.

I have been feeling very high palpitations. Heart rate is always above 90. Sometimes it crosses 120-130 range.
Is it a bad thing, i mean i dont know the reasons of this.  Requesting some suggestions. 

All thals friends have these issues ? What's your heart rate during normal times & pre-post transfusion ?

Thanks

any new updates ? Please share the information about gene therapy in India also.

Hello everyone. My name is Ricardo and my son Gabriel has Thalassemia Intermedia. We live in Brazil. Gabriel's 17 years old and will finish High School this year. He wants togo to Australia next year for one year undergraduate student program. We are looking for health insurance plan that covers pre existing conditions in order to he can continue his treatment there, but we are facing difficulties to find such coverage. Has anyone faced the same problem? Any suggestion? Thank you so much.

Thank you for this post and sharing your research.

One question on IRON. You mentioned iron levels should be monitored. Is that true for Thal Minor also or for Thal Majors ? Do Thal Minor need to be careful about iron-containing foods ?