The instructions from Novartis specifically do say that the tablets should not be chewed.
http://www.thalassemiapatientsandfriends.com/index.php?topic=1928.msg16165#msg16165Take Exjade once daily on an empty stomach at least 30 minutes before food, preferably at the same time each
day. Do not chew tablets or swallow them whole. Do not take Exjade with aluminum-containing antacid
products. Calculate doses (mg/kg per day) to the nearest whole tablet. Completely disperse tablets by stirring in
water, orange juice, or apple juice until a fine suspension is obtained. Disperse doses of <1 g in 3.5 ounces of
liquid and doses of ≥1 g in 7.0 ounces of liquid. After swallowing the suspension, resuspend any residue in a
small volume of liquid and swallow.