• Welcome, Guest. Please login or register.
    November 27, 2020, 12:09:29 PM

  • Login with username, password and session length

Sajid's dove

Tell everyone they can now find this site by typing this into their browser:

thalpal.com

Click to visit us on Facebook


If you have any problems registering or signing in, please send an email to: andythalpal@yahoo.com
Please do not send questions about thalassemia to this address.


Administrators
Andy
Danielle

Thalassemia Patients and Friends and thalpal Ā© A. Battaglia 2019





55407 Posts in 5930 Topics by 6250 Members
Latest Member: Elisa825

A message for all  parents who are thals. Keeping your iron load under control is an absolute obligation to your children.
« previous next »
Pages: 1 Go Down Print
Author Topic: Successful Treatment for Mice With Beta-Thalassemia  (Read 2613 times)
7assan
I wish you a speedy recovery
Junior Member
***
Offline Offline

Location: Kingdom of Bahrain

Gender: Male
Posts: 113



« on: November 23, 2010, 02:04:50 PM »

Tuesday, November 23, 2010
Beta-thalassemia is an inherited blood disorder that results in chronic anemia.

A major complication of the condition is iron overload, which damages organs such as the liver and heart. The iron overload has been linked to low levels of the protein hepcidin, a negative regulator of intestinal iron absorption and iron recycling. A team of researchers, led by Stefano Rivella, at Weill Cornell Medical College, New York, has now shown that increasing the concentration of hepcidin in beta-thalassemic mice limits iron overload and markedly reduces their anemia. They therefore suggest that therapeutic approaches that increase hepcidin levels in patients with beta-thalassemia could be therapeutic, limiting iron overload and mitigating anemia.

In an accompanying commentary, Mark Fleming and Thomas Bartnikas, at Children's Hospital Boston, discuss these data and suggest that modulating hepcidin levels could be a new approach to treating a multitude of diseases associated with iron overload or deficiency.

***

TITLE: Hepcidin as a therapeutic tool to limit iron overload and improve anemia in beta-thalassemic mice

AUTHOR CONTACT:
Stefano Rivella
Weill Cornell Medical College, New York, New York, USA.
Phone: 212.746.4941; Fax: 212.746.8423; E-mail: str2010@med.cornell.edu.
View this article at: http://www.jci.org/articles/view/41717?key=c4981adf3d5ea08a7e57

ACCOMPANYING COMMENTARY
TITLE: A tincture of hepcidin cures all: the potential for hepcidin therapeutics


AUTHOR CONTACT:
Mark D. Fleming
Children's Hospital Boston, Boston, Massachusetts, USA.
Phone: 617.919.2664; Fax: 617.730.0168; E-mail: mark.fleming@childrens.harvard.edu.
View this article at: http://www.jci.org/articles/view/45043?key=a84ffb2845dc5e10e863

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Source: Journal of Clinical Investigation


http://www.checkorphan.org/grid/news/research/successful-treatment-for-mice-with-beta-thalassemia
Logged
Pages: 1 Go Up Print 
« previous next »
Jump to:  

Powered by MySQL Powered by PHP Powered by SMF 1.1.21 | SMF © 2015, Simple Machines Valid XHTML 1.0! Valid CSS!