• Welcome, Guest. Please login or register.
    April 23, 2019, 07:59:27 PM

  • Login with username, password and session length

Sajid's dove

Tell everyone they can now find this site by typing this into their browser:

thalpal.com

Click to visit us on Facebook


If you have any problems registering or signing in, please send an email to: andy@thalpal.com
Please do not send questions about thalassemia to this address.


Administrators
Andy
Danielle

Thalassemia Patients and Friends and thalpal © A. Battaglia 2018





55001 Posts in 5847 Topics by 6100 Members
Latest Member: faithxalways

Forum Tip: 
Put your birthdate in your profile, under "Forum Profile Information," and it will automatically come up on our calendar.
« previous next »
Pages: 1 Go Down Print
Author Topic: Beta-2 microglobulin (B2M) Test  (Read 493 times)
Canadian_Family
Supreme Member
*****
Offline Offline

Posts: 1064



« on: March 01, 2019, 09:56:31 AM »

Hi,

Just like to share the information, lately patients who are on Exjade or Jadenu were routinely tested for ACR (Albumin to Creatinine Ratio). This test usually shows kidney function disruption (if any) quite late. To early detect the Kidney function, doctors have started Beta-2 macroglobulin test (normal range is 0-29).

Beta-2 microglobulin (B2M) is a protein that is found on the surface of nucleated cells (contain a nucleus) and functions as part of the human immune system. This protein is routinely shed by cells into the blood and is present in most body fluids, with highest levels in the blood, generally lower levels in spinal fluid, and trace levels in urine.

In the kidneys, B2M passes through blood-filtering units called the glomeruli and is then reabsorbed by the renal proximal tubules, structures that reclaim water, proteins, vitamins, minerals, and other vital substances. Normally, only small amounts of B2M are present in the urine, but when the renal tubules become damaged or diseased, B2M concentrations increase due to the decreased ability to reabsorb this protein. When the glomeruli in the kidneys are damaged, they are unable to filter out B2M, so the level in the blood rises.
Logged

Regards.
Andy Battaglia
Administrator
Supreme Member
*****
Offline Offline

Location: In my heart, Maldives

Gender: Male
Posts: 8546


Will thal rule you or will you rule thal?


« Reply #1 on: March 03, 2019, 12:10:01 PM »

There is a lengthy report on Incidence of deferasirox‐associated renal tubular dysfunction in children and young adults with beta‐thalassaemia at https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.13002.

Damage to the renal tubes is a well known issue in thalassemics (this occurs even in thal minors, to a lesser extent), but apparently the Exjade drugs can cause the damage to increase, especially in certain classes of patients.
Quote
In conclusion, we demonstrate that asymptomatic renal tubular dysfunction was very frequent in a small cohort of predominantly oriental β‐thalassaemic patients who receive deferasirox; they are much more likely to develop renal tubular dysfunction with concomitant metabolic acidosis and electrolyte disturbances when compared to patients on other chelation regimens. If discovered early, it is reversible with either dosage reduction or withholding treatment. Vigilant monitoring of renal tubular dysfunction and serum electrolyte levels is recommended in patients who receive deferasirox therapy.
Logged

Andy

All we are saying is give thals a chance.
Canadian_Family
Supreme Member
*****
Offline Offline

Posts: 1064



« Reply #2 on: March 04, 2019, 10:18:54 AM »

Thanks Andy. Little Miss A results are critically high for Beta-2macroglobulin test. Her number is 3000 compared to normal range of 0-29 (test done in Dec 2018). The ACR values are mildly high at 3.9 compared to normal range of 1-3.5

This early deduction test (B2M) just started as of December 2018. She is off Jadenu for the last two months, we are waiting for the result of repeat test soon. Will keep posted.
Logged

Regards.
Pages: 1 Go Up Print 
« previous next »
Jump to:  

Powered by MySQL Powered by PHP Powered by SMF 1.1.21 | SMF © 2015, Simple Machines Valid XHTML 1.0! Valid CSS!