Discussion Forums > Thalassemia Major

Development of Jaundice like syptoms in thal patients

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Gabri:

--- Quote from: ZAINI on June 26, 2007, 11:44:08 AM ---Does this make a big big difference?,I mean shall i go to blood bank people and request personally to deliever the blood drawn in last three days for my daughter,bcoz it doesn't happen always?

ZAINI.

--- End quote ---

Hi Zani,

It will make a notavel difference if you get fresh blood or if the bloodlettig was 14 days ago. For a "healthy"  who need transfusion after a big surgery it is not important because he has a healthy blood system and within a few day his bone marrow will reproduce the lost blood. This will not happen in thals.

At the other way we can be happy to recive blood. Sometimes it is not possible to get this fresh red cells so it is ok to recive what is disponible.

Zaini:
Hi Gabri,

Thanx for replying, i never knew that thing about blood,so whenever at hospital on transfusion day,the staff told me the collection date and the expiration date, i always thought that it's good to be confirmed that the blood is not expired,but i never counted the days from collection till transfusion,but this time when we went for transfusion i noticed the date ,it was about 15 days old, it is really concerning me,i don't know what should i do, go to the blood bank people and request them for freshly collected blood for my daughter's transfusion,but i highly doubt they'd respond positively,so for the moment i think it's better to let things be as they are.

ZAINI.

§ãJ¡Ð ساجد:
Hello Mr. Tariq,

Sorry I couldn't go to JSF earlier as the weather had been quite bad lately. However, yesterday I went to JSF as I had an appointment and the weather had calmed down too.

I asked the doctor about your baby having Jaundice after the TransX. She asked to check some attribute in the Blood CP (which I forgot, sorry). If that was normal then she said that it is unlikely that she got a reaction from the blood and the jaundice could have been triggered by Hep-A virus. I asked her about using the filter and she said that using the filter is could not prevent it.

I think she said that because Hep A is most commonly transmitted via oral tract which she received some time before the TransX and eventually gave her the symptoms later.

Take care.

mrtariqkhan:
Hi,

   Thanks for the update...  Well, i took her to a couple of specialists and Hep-A virus doesn't go away in a day or two.... i know coz i have suffered from it once  :wah... (Took me 1 and half month to recover completely)

   I think the best and conclusive answer to what happened is the reply from Andy:

--- Quote ---Yes, the reason for the yellow color and high bilirubin is the excess hemolysis or break down of the transfused red cells. This happens because antibodies in the blood react to the antigens in the donor blood. These antibodies are increased in the blood due to previous transfusions. The more one is transfused, the more one accumulates these antibodies. This is why using a filter or filtered blood is so important. Removing the white cells and the antibodies contained in them is very important in improving the survival of the transfused red cells and also avoiding transfusion reactions. As you suggested, accurate cross matching is also a very important factor in avoiding excessive hemolysis.

If at all possible, use a filter during transfusion. One other thing that may help is using prednisone along with the transfusions. This can help counteract the immediate antibody reaction and lead to longer life for the transfused red cells. Perhaps Sharmin can share her experiences with her son regarding this.
--- End quote ---


    So i am and the docs are pretty convinced that it wasn't Hep-A virus infection.  as the SGPT values were pretty low, they are the main indication for Hep-A virus

  Anyhow, I will talk to them again in this regard and act on advice of Andy and use ( Filter and Prednisone) so as to retain the life of RBC's .


Thanks Again
Take Care

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