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STEM CELL THERAPY!!
Zaini:
Guys!
Pardon me, i didn't know what i was talking about when i said i haven't ever heard about stem cell therapy, i was just searching for some more information about retrodifferentiation and i came across this.
FROM http://www.hsipl.com/pages/solutions_sct_procedure.html
--- Quote ---Stem Cell Therapy Procedure
The actual procedure consists of inserting a fistula needle in a peripheral line. Should vene-puncture in the peripheral line not be possible, a central venous pressure (CVP) line in the format of an inner jugular line, a sub-clavian line or a femoral line, depending on the patient’s age, size condition and indication, is inserted into the patient using local anesthesia and a return catheter into the opposite arm." This is done by our qualified ICU doctor / anesthetists. The CVP line is then hooked into an apheresis machine (GAMBRO COBE Spectra) which separates a volume of the patient's blood into 3 parts: Red Blood Cells, White Blood Cells and Platelets. The Red Blood Cells and Platelets are returned to the patient immediately via the machine. A small volume of the White Blood Cells depending on the patient's age, weight, height, size and condition are taken and converted into pluripotent stem cells via a process of Retrodifferentiation (addition of a monoclonal antibody to a particular cell surface contact receptor). These cells are then given a direction to re-differentiate into the required cell type (progenitors). After the require time of incubation, the stem cells are then washed in a GAMBRO COBE 2991 Cell Processor and re-infused into the patient. The whole process takes between 6 and 8 hours. The CVP line is removed an hour later and the patient is then monitored for a period of 24 to 48 hours and then discharged.
Therapy Side Effects
There have been no negative side effects in any of the 86 patients that have undergone this treatment for various diseases. There have been very positive side effects such as the curing of Psoriasis in patients with Aplastic Anaemia. Patients have a higher energy level after the procedure as compared to before the procedure
Regulatory Approvals
The procedure is not FDA or EMEA approved as yet. Data from the human studies in Pakistan has been compiled and prepared for submission to EMEA and the FDA shortly.
Patients Treated To-Date
The total number of patients that have been treated using Retrodifferentiated Stem Cell Therapy since March 1, 2005 are as follow:
BETA THALASSEMIA MAJOR
We treated 28 patients in Beta Thalassaemia Major who required between 2 and 7 blood transfusions in a 2 month period with iron overload measured by Ferritin ranging from 1250 to 11,300. 90 days following the treatment their blood transfusion requirements fell to between 1 and 3 transfusions. Their serum Ferritin levels fell to normal levels WITHOUT the use of any chelating agent such as Desferal or Feriprox. Their distended stomachs reduced in size indicating organ repair and normalization. Thalassaemia Major is a genetic disease in which the patient's red blood cells break down. The only treatment known is to transfuse the patients with cross matched blood. Transfusion may lead to the patient getting viruses in unscreened blood and additional iron from the donor. This iron overload is what eventually kills the patients. Average life of patients is between 7-10 years.
Thalassaemia Intermedia
This is milder form of Thalassaemia Major. The patient has recovered without requiring more than one transfusion in a 10 month period. The patient was sickly and bed ridden every two weeks due to weakness. 10 months later, he has gained weight and does not require any transfusion or chelating agents of any kind.
Sickle Cell Anaemia
This is milder form of Thalassaemia. The patient has recovered requiring only one transfusion in a 7 month period. The patient was sickly and tired every two-three weeks due to weakness. In this 7 month period, he has gained weight and does not require any transfusion or chelating agents of any kind.
--- End quote ---
And do you wanna know how much does it cost for thals? In between 6 to 8000 Pakistani rs,Isn't it too good to be true?OR IS IT TRUE?
Please do visit this site.
ZAINI.
§ãJ¡Ð ساجد:
Hi Zaini,
This is the retro-differentiation process that Tri Stem had been experimenting here with my cousin's colleague. Now they have gone underground (or abroad) and it is no longer done in public. ???
I hope Manal can catch up with their experts in Egypt to let know about the public availibilty of the project and feasibility as it is a treatment and not a cure as it extends the transfusion period.
Zaini:
Hi Sajid,
I called them today and they didn't say any such thing,and plus i saw an update on another forum according to which our president Musharraf himself presided their launching ceremony,so i hope they are not underground,and i don't know but if you visit their site,they have two seprate sections,one is about stem cell therapy and another is about retrodifferentiation,and as far as i remember when in the very beginning we went to meet them,that person told us that the cost of per session for retrodifferentiation is about 3 to 4 lacs, where as stem cell therapy is concerned,the cost showed on site is 6000 t0 8000,anyways i am going to search about it as much as i can.
ZAINI.
Andy Battaglia:
If you read through the FAQ section, you will see that
http://www.hsipl.com/pages/solutions_retro_faqs.html
--- Quote ---How long will it be before your technology is available to patients?
Retrodifferentiated Stem Cell Therapy to treat various disorders is available now at Park Lane Hospital in Karachi, Pakistan. Very shortly there will be another location opened in the Caribbean. Please call or send an e-mail about opening date of the second facility.
--- End quote ---
Apparently, this therapy is now available in the country where it was first developed. :biggrin
I would hope that some of our members in Pakistan will contact them directly and ask about their success rates and how long patients are able to skip transfusions after the process has been done. In fact, please feel free to invite a representative from the company to join our site and present their information, just as has been done in the past with the people from Ferriscan.
Zaini:
Hi Andy,
Yes i am going to do that, just let me get hold of this person, he is out of country right now, this hospital is not so far from my place, infact i see it on daily basis on my way to pick my son from school.Let's hope for better.
ZAINI.
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