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Erythrocyte Morphology

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phyrefly:
Little has been written of the comparison of erythrocyte morphology in thalassemia as it relates to other cases of abnormalities caused by genes and/or parasites. The blood-sucking tick, Haemaphysalis traguli occurs in Southeast Asia. Its host is the Lesser Mouse Deer, Tragulus javanicus. The genus Haemaphysalis also occurs on Red Jungle Fowl, Gallus gallus, precursor to the dometicated chicken. Here is shown connections to erythrocyte morphology in species other than humans.


http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed
(Type in abstract number)

Erythrocyte Morphology / Roan Antelope (Hippotragus equinus)   16542675

Lesser Mouse-Deer (Tragulus javanicus)  8771414
(Host to Haemaphysalis traguli)

Punctate Basophilia / Thalassemia  2214342
(Russian punktirovnyi 'punctate')

Platelet Shape Change / Ornithodorus savignyi  11932256

Thus, there exists evidence to support the hypothesis that pathogens also influence genetic mutations and morphological abnormalities.

§ãJ¡Ð ساجد:
Wow! Thanks for the great resource :)

You won't find this info even on your favourite wildlife channel  :wink :biggrin

phyrefly:
Al Salaam, Sajid,

Ticks are notorious vectors of Rickettsia, Borrelia, etc. Connections to influenza, Hepatitis B virus and influenza will be forthcoming. Pakistani studies on erythrocyte morphology in tick-borne disease could include Ornithodorus tholozani, vector of Persian relapsing fever as well as vectors of the Spotted Fever Group Rickettsia, of which the tick genus Dermacentor is an example.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed

Thalassemia / Rickettsia   16462712
(The article mentions Rickettsia)

Borrelia / Thalassemia  11399112

Haemaphysalis danieli / Pakistan  864574
(Hoogstraal was also stationed at NAMRU-III in Cairo)

West Pakistan  4734280

Chicken Anemia Virus  16081905

SARS / CD147  15688292

CD147 / Erythrocyte Trapping  11389044

Gallus spp. / Erythroid Proliferation  2618752

§ãJ¡Ð ساجد:
Asalam-o-Alaikum,

Are you from Pakistan and a doctor? If yes then let us know where to find you as there are a couple of Pakistanis on this forum and we might want to contact you. I know, I want to!

phyrefly:
Asalam-o-Alaikum,

No, not a physician nor residing in Pakistan. Located in the U.S., I'm wondering whether there are some speculations involving thalassemia that can be brought forth here at this forum to support the proposal that thalassemia patients may be more susceptible to hepatocarcinoma way earlier than non-thalassemia-hepatitis patients. Thus, one speculation involves the use of Schisandra chinensis and other species of this plant genus as relates to hepatitis and cirrhosis therapy. In particular, compounds such as the gomisins for the liver as these may stimulate or maintain erythropoietin production in thalassemia. Is there a synergy twixt flavonoids and gomisins? Why is Schisandra used to rejuvenate race-horses? Physicians may wish to consider Schisandra use for those compromised with both thalassemia and hepatitis.

On another note, reading up on erythrocyte morphology from a medical text (written by four prominent physicians, to be referenced here shortly), it seems that lipid synthesis comes under scrutiny as it relates to the erythrocyte membrane. The question being: 'Why are the erythrocytes of the mouse-deer the smallest known of any animal?' and 'What causes the mouse-deer erythrocyte membrane to invaginate (create pits) on the erythrocyte surface?' and 'What forces may have created a unique cross-talk between these and blood plasma? 'What parameters, if any, have blood-sucking ticks played in erythrocyte morphology?' Implicated in this morphology is the acyl moiety in cholesterol. Spiculated erythrocytes signal too much cholesterol, but what of the reverse of this situation?

 Implicated as well, will be the mechanism of deacylation in improving DNA delivery. This improvement in delivery made it possible to home in on mouse lung cells. Since we already have CD147 and SARS to ponder, there is the fact that H5N1 avian influenza prefers attachment sites deep in the human lung rather than, say, in the upper bronchia or throat. A more pandemic mutation would be that the H5N1 virus could use attachment sites less deep in the lung. Acylation and de-acylation then, is included in a discussion of erythrocyte lipid membrane morphology.

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