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Manal:
Hi Mariam
When hemolysis occurs (the breaking of the red blood cells ), there is a waste that comes out of this process called bilirubin. Bilirubin is the reason that non transfused thal have jaundice (their skin, the white of the eyes, all body fluids like urine becomes yellow in colour). Excess of bilirubin may cause stones to build in the gall bladder.
From my knowledge, transfused thal and especially who have frequent transfusions don't have a high rate of bilirubin since they are maintaing a high HB?
Please Andy advice
manal
aysam:
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poo gill:
dont worry dearie, prat's bilirubin are always high. it is to do with haemolysis(breaking of cells) in their body. Vishal's bilirubin is also normally on the high side - this is how we know even when we are minors haemolysis is happening to them.
I need to check with someone on Aysam's Bilirubin results. let me study this for a while. meanwhile you see the pics which manal helped me to upload and njoyyyyyyyyy.
Guys - finally the pictures are up for viewing, sorry for the delay.
Luv
puja
Manal:
Mariam, i really don't intend to scare you and as Puja said intermedias has high bilirubin as my son his total bilirubin is ( 1.8 to 2 ) , so from this came my question. Having aysam transfusing, should result in less bilirubin compared to non transfusing. That is why i am wondering and i think you have to check with the doctors.
By the way Mariam, does Aysam suffer from any other thing or there is another genetic disorder that runs in the family???
manal
poo gill:
mariam
I checked prat's reports when he was 2.5 years but it only shows that Aysam's alkaline phospates are much lower than Prat. Prat was 333.
normally total bilirubin consists of conjugated and un conjugated. So accroding to the rport which you have enclosed looks like that uncojugated has gone from 2 to 3 that is y total is 5.
I read this on the medical dictionary:
bilirubin
an orange bile pigment produced by the breakdown of heme and reduction of biliverdin; it normally circulates in plasma and is taken up by liver cells and conjugated to form bilirubin diglucuronide, the water-soluble pigment excreted in the bile. Failure of the liver cells to excrete bile, or obstruction of the bile ducts, can cause an increased amount of bilirubin in the body fluids and thus lead to obstructive or regurgitation jaundice.
Another type of jaundice results from excessive destruction of erythrocytes (hemolytic or retention jaundice). The more rapid the destruction of red blood cells and the degradation of hemoglobin, the greater the amount of bilirubin in the body fluids.
Most bilirubin is excreted in the feces. A small amount is excreted in the urine as urobilinogen.
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conjugated bilirubin
bilirubin that has been conjugated, mainly to glucuronic acid, in the liver and gives a direct result to the van den bergh test. High blood levels indicate obstructive or hepatocellular origin of the jaundice.
Bilirubin
A pigment produced by the liver that is excreted in bile which causes a yellow discoloration of the skin and eyes when it accumulates in those organs. Bilirubin levels can be measured by blood tests, and are most often elevated in patients with liver disease or a blockage to bile flow.
unconjugated bilirubin
bilirubin that has not been conjugated in the liver. It gives an indirect reaction to the van den bergh test. A high level of it in the blood is indicative of hemolysis or a lack of bilirubin clearance by the liver. Called also free bilirubin.
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I dont understand these values at all as I dont have any reference.
alanine txaminase 58 H 134
gamma-gluttxferase 14 16
What did the doctor tell you for this report. Is he looking jaundiced???????????? manal do u understand the above 2 terms.
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