Discussion Forums > Diet, Nutrition and Supplements
SUPPLEMENTS FOR CHILDREN
Sharmin:
Narendra,
Although I don't have a definitive answer to that question - I am basing it on the reasoning given for using vitamin C 1/2 hr after desferal infusion is started.
Vitamin C is thought to release iron stores from the liver - when administered with desferal infusion it increases the iron available for desferal to bind and remove from the plasma. Vitamin C is given when some desferal is available in the blood stream and will then be available for 9.5 to 11.5 hrs continuously after.
If we use this reasoning with Exjade, it is known that Exjade has a longer half life so it is available in the body for up to 14 hours after consumption. Technically, if vitamin C is taken 1/2 hour after Exjade the same might apply as desferal. I don't know if the Exjade is also as efficient as desferal at removing free iron from the plasma but I know that it should bind some free iron from the plasma and excrete it.
The story for L1 is different because of the shorter half life - so if the L1 is taken several times a day MAYBE - the same logic would apply - taking vitamin C with it would improve chelation.
I am guessing that vitamin C for enhancing chelation purposes probably apply mostly to desferal - because desferal does not tend to work as well at the tissue level - instead it does a better job of removing iron from plasma. L1 and Exjade do remove iron at the cellular/tissue level therefore the need for vitamin C is not the same.
Vitamin C for L1 and exjade users may be more for the other protective benefits that it provides. As far as safety - I would imagine that vitamin C is safe to give with a dose of any chelator because the chelators are present to bind the free iron released from the liver by the vitamin C. However, a good doctor should be consulted because this deduction is limited by my 'logic'.
Remember too that taking vitamin C with no chelator on board may be hazardous to thalassemia patients for two reasons:
1. it increases the iron absorption from food
2. It releases free iron from the liver - which is then available to damage the organs because no chelator is present to bind it.
Sharmin
Sharmin:
Andy,
Can you help me answer and expand on the use of vitamin C and its use with Exjade and L1?
I know that thals should not use it if there isn't a chelator on board because it releases free iron from the liver - and that it aids desferal by means of this mechanism, as desferal removes free iron from the plasm. Should it be safe to use vitamin C in the same way with L1 and exjade? I also hope to have my son on exjade for the most part in the future - but I really want to continue to give him vitamin C (to 250 IU as dr. vichinsky advised). Since we have increased his dose of vitamin C he does not bruise and seems to be doing very well. While reveiwing our vitamins he remarked that the 100 IU we were giving was 'not enough'.
Sharmin
Ayesha:
Manal!!!! thanks a ton for those details, now another task for you guys *me loves to bug you guys :rotfl :rotfl :rotfl :rotfl :rotfl :rotfl :rotfl *
my tablets of vitamins and calcium and everything is over, and i gonna buy them this week, now I want you to suggest me dose and tablets, what shud i take? and how much?
my weight is 55 :$ and age 21 :)!
waiting for detailed reply hehehe :D
and am not sorry for buggin :D :D :D :D :D!
Zaini:
Ayesha,
Although i am not a doctor but i'll advise you some brands,but please check with the doctor first,
I think you should be taking,Folic acid,(Folitab or any other tab,daily),calcium +Vitamin D (Chew cal ,daily),half a tab of Abocal after starting desferal,Vitamin E (Tokosvit 1 or two tabs,daily),Zincat syrup (containing Zinc,two spoonful,daily).I am sorry i am unable to locate any brand containing megnesium.Add a multi vitamin with out iron and with out a high dose of vitmin C.For that you'll have to bug the chemist :biggrin.
Along with all these my daughter is taking IP6,wheat grass and carao.
Anything else you want to ask,i'll be happy to answer :hugfriend.
Zaini.
Ayesha:
Thanks alot for the reply Zaini! i appreciate it :)!
there is tablet I asked from Chemist: Supradyn-N contains:
[Copper:1mg, Phosphorus:25.5mg, Zinc Oxide:0.5mg, Thiamine HCl (Vitamin B1):20mg, Tocopherol (Vitamin E):10mg, Retinol (Vitamin A):3333IU, Riboflavin (Vitamin B2):5mg, Nicotinamide:50mg, Molybdenum:0.1mg, Manganese:0.5mg, Folic Acid:1mg, Iron Salts:50mg, Magnesium Oxides and Hydroxides:18.8mg, Cyanocobalamin:5mcg, Biotin:0.25mg, Calcium Pantothenate:11.6mg, Calcifediol:500IU, Ascorbic Acid:150mg, Pyridoxine:10mg, Calcium:50mg]
and Revitale-B contains:
[Inositol:10mg, Pantothenic Acid:12mg, Thiamine HCl (Vitamin B1):2.8mg, Riboflavin (Vitamin B2):3.2mg, Nicotinic Acid:36mg, Folic Acid:400mcg, Cyanocobalamin:2mcg, Biotin:0.15mg, Pyridoxine:4mg]
now tell me guys is it ok to take any of them? Supradyn contains IRON SALTS :S 50 mg :S and yes here is another: Centra Silver
9 WATER SOLUBLE VITAMINS
Vitamin B1 1.5 mg
Vitamin B2 1.7 mg
Vitamin B6 3 mg
Vitamin B12 25 mcg
Niacin 20 mg
Biotin 30 mcg
Pantothenic Acid 10 mg
Folic Acid 200 mcg
Vitamin C 60 mg
5 VITAL MINERALS
Calcium 200 mg
Magnesium 100 mg
Potassium 80 mg
Phosphorus 48 mg
Chloride 72 mg
Lutein 2.5 mg
4 FAT SOLUBLE VITAMINS
Vitamin A 6000 IU
Vitamin D 400 IU
Vitamin E 45 IU
Vitamin K1 10 mcg
12 TRACE ELEMENTS
Iron 9 mg
Zinc 15 mg
Iodine 150 mcg
Copper 2 mg
Selenium 25 mcg
Manganese 2.5 mcg
Chromium 100 mcg
Nickle 5 mcg
Silicon 10 mcg
Vanadium 11 mcg
Molybdenum 25 mcg
Boron 150 mcg
it contains 9 mg Iron
I still can't find any multivitamin widout IRON :|
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