Discussion Forums > Thalassemia Major

ANDY SIR PLZ HELP

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jatinder:
DEAR ANDY,

i m taking ferriprox at the dose of 7 tabs(500mg each) per day.

and the problem is when i take the tabs the urine comes red colour.

so i m doubt that isnt this blood.

does the urine comes red when taking ferriprox.

plz help me

Andy Battaglia:
Iron being chelated causes red urine with desferal and to some extent with L1 also. This varies from patient to patient and is related to iron load and dose of the drug.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2376085


--- Quote ---Reddish discoloration of urine due to excretion of the iron-deferiprone complex has been reported in Deferiprone (DFP, Ferriprox™, Kelfer™, L1, CP20) treated patients.
--- End quote ---

http://cat.inist.fr/?aModele=afficheN&cpsidt=14871185


--- Quote ---It increases urinary iron excretion, which mainly depends on the iron load of patients and the dose of the drug. It decreases serum ferritin levels and reduces the liver and heart iron content in the majority of chronically transfused iron loaded patients at doses >80 mg/kg/day. It is metabolised to a glucuronide conjugate and cleared through the urine in the metabolised and a non-metabolised form, usually of a 3 deferiprone: I iron complex, which gives the characteristic red colour urine.
--- End quote ---

Lena:
Do not worry, it does come red. I also take 7 ferriprox per day and it happens the same. It is good that it comes red. It shows you have iron to be chelated.The redder,in fact, the better and if you take vit c, it will help more.

Andy Battaglia:
Lena,

Because there have been no studies done with L1 and vitamin C, we have to rely on personal reports on how it has worked for people. How long have you used vitamin C with Ferriprox and how much do you take daily?

jatinder:
thanx andy and lena for help and getting me out from this doubt.

well well  is it necessary  to take vitamin c with ferriprox. :huh
i dont take that one.

thankx and rgrds :hugfriend :hugfriend
jatinder kewlani

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