Discussion Forums > Diet, Nutrition and Supplements
Multivitamins for thal major children
nice friend:
Thanx Andy ,
i was confused abt the dosage and administration of vit-c , but its clear now that if i have started chelation regularly then its safe to take 250mg of vit-c ... after its a long time to when i started chelation with pum today i gave my tummy a littlee rest and i m having desferal IV , soo i took 250mg of vit-c after 1 hour to starting time of chelation.... thanx buddy. ..
Take Care
Umair
Dori:
Ehhhhh ??? Oh help! I thought we weren't allowed to take vitc. I thought that for 2 years, untill i came here. But deficient in vit. C?
I think i start to do research in my holidays. I need to take more vit. So you will have homework during the holidays;)
Sharmin:
Dear Dore,
The facts about vitamin C in thalassemia major are as follows,
There is often significant vitamin C deficiency in thalassemia major. Vitamin C is necessary for among reasons, the immune system, the circulatory system (healing bruising), bone health, and health of the skin.
There are two problems with taking vitamin C in thalassemia - therefore vitamin C doses must be timed very well.
1) Vitamin C increases iron absorption in the gut - therefore it should not be taken with meals (especially meals high in iron)
2) Vitamin C causes iron to be expelled from the liver - therefore free iron is available to damage other organs - therefore vitamin C is best taken 1/2 hour after the beginning of desferal infusion.
If vitamin C is taken 1/2 hour after starting desferal then it can be helpful - because desferal cannot enter organs to remove iron - so if vitamin C can release iron from the liver desferal has more iron to bind and remove from the body. My 29kg son takes 250mg of vitamin C after beginning desferal infusion. This serves two purposes for him, it helps chelate more iron and it restores the vitamin C in his body to counteract vitamin C deficiency.
Dore, I know that you are not able to tolerate desferal - we are currently trying to determine whether it is okay to take a dose of vitamin C with exjade - because the mechanism by which exjade chelates is different than desferal. We don't know if exjade would mop up the iron released into the blood stream as efficiently as desferal does.
Remember, by storing most of the iron (to a certain level) the liver protects the other organs from iron damage - therefore we don't want to release stores of iron from the liver without having anything to quickly remove this iron from the body. Perhaps in your case (we don't have enough information at this time) - tiny doses of vitamin C can be taken between meals because vitamin c is quickly metabolized and removed from the body it should not cause any cumulative issues.
Andy is the expert on vitamin C - perhaps he can shed some more light on this :)
I hope this helps Dore :)
Sharmin
Dori:
Thank, your information does help.
Today I had write my memo for property law, but I also was searching on pubmed. Accidentically, I found the article what goes about me. It's funny to read it. Now I know more about my own enzyme defect.
--- Quote ---In a 2-yr old girl a hemolytic anemia was present since birth requiring multiple blood transfusions
--- End quote ---
http://www.ncbi.nlm.nih.gov/pubmed/2220762?ordinalpos=346&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
(it's a pity that there's only this)
Also a dutch person has written a thesis about pk def. We got his thesis, but I never read it. I think my father did. I am looking for it. Don't worry I know that there's a possiblitlity that I won't pass page 3 :wink
Once again: Muchas gracias :smileblue
sahil:
Hello,
I started with Centrum Silver a month back. One tablet daily. Is that cool enough or I need something more?
\peace/
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