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Effect of L-carnitine on the physical fitness of thalassemic patients.

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Andy Battaglia:
Acetyl-L-carnitine (ALCAR) is a form of L-carnitine and can be used. As a supplement, acetyl-L-carnitine (ALCAR) may be better absorbed than carnitine.

http://lpi.oregonstate.edu/infocenter/othernuts/carnitine/


--- Quote ---L-Carnitine Supplements

While bioavailability of L-carnitine from the diet is quite high (see Dietary L-Carnitine), absorption from oral L-carnitine supplements is considerably lower. Supplemental L-carnitine is mainly absorbed by passive diffusion (1). According to one study, bioavailability of L-carnitine from oral supplements (0.5-6 gram dosage) ranges from 14%-18% of the total dose (5). Less is known regarding the metabolism of the acetylated form of L-carnitine, acetyl-L-carnitine (ALCAR); however, bioavailability of ALCAR is thought to be higher than L-carnitine. The results of in vitro experiments suggest that ALCAR is partially hydrolyzed upon intestinal absorption (10). In humans, administration of 2 grams of ALCAR per day for 50 days increased plasma ALCAR levels by 43%, suggesting that some acetyl-L-carnitine is absorbed without hydrolysis or that L-carnitine is reacetylated in the enterocyte (5).
--- End quote ---

For some further updates about L-carnitine, see my next post, Lipoic acid and acetyl-carnitine reverse iron-induced oxidative stress.

Andy Battaglia:
Thalassemia majors do want to suppress the bone marrow, while non-transfusing intermedias do not, so this distinction should be made in the context of taking L-carntine.

Zaini:
Andy,

Do you think Little Z should be taking L-Carnitine? This thal major and thal intermedia thing you said got me a bit confused  :huh .

Is it correct that L-Carnitine is also used by body builders? If yes then it should be available here,,i'll have to search for it in the right places i guess.

Zaini.

Manal:
Maha

This is the rand i use (syrup)
http://www.mepaco-pharma.net/html/Get-trades.asp

As Andy said it will be okay for you to use what you have in Saudi Arabia
If you want to ask about anything else, let me know

Zaini

All the studies made on L-carnitne were done on thal major patients and was found to have many important benefits which where mentioned above. What i know is that it is given to thal major and intermedias here and on the basis of 5 days per week

Yes, body builders also use it as L-carnitine improves atheletic performance too that is why you will find that little Z will be little more active when she takes it

manal

Dori:
I found L-carnitine on my search, but I will not take it.

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