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Lipoic acid and acetyl-carnitine reverse iron-induced oxidative stress

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Sharmin:
Thank you very much Andy. 
Sharmin

Dori:
Hello,
I have found a new person with pkd. She's in her 55's and was transfused until the age of 11. Then she had her spleen removed. From that on she only gets a blood transfusion when she has been ill and her general level of hgb is between 6 and 7. She's American so I believe she talks about gl/dl. Her doctor has determine she has an elevated (sp?) level of ferritin but the range is unknow to her. She was describedd Exjade which she refused because she went online and found the article at wikipedia. She did her own research and now takes only alpha lipoic acid to chelate. This is beyond my understanding, but I found this topic on thalpal. Could someone help me a bit. Is this an adequate way to chelate. Does someone use it? Has it been proven to chelate (so far I have not found an article that says it does).
Thank you in advance,
Dore
PS No, I havent restart Exjade yet.

Narendra:

--- Quote ---I have found a new person with pkd. She's in her 55's and was transfused until the age of 11. Then she had her spleen removed. From that on she only gets a blood transfusion when she has been ill and her general level of hgb is between 6 and 7. She's American so I believe she talks about gl/dl. Her doctor has determine she has an elevated (sp?) level of ferritin but the range is unknow to her. She was describedd Exjade which she refused because she went online and found the article at wikipedia. She did her own research and now takes only alpha lipoic acid to chelate. This is beyond my understanding, but I found this topic on thalpal. Could someone help me a bit. Is this an adequate way to chelate. Does someone use it? Has it been proven to chelate (so far I have not found an article that says it does).
--- End quote ---

Unless we know her exact ferritin levels, it is difficult to comment. Elevated levels of ferritin can be anything above the normal range. If her ferritin level is above normal, she needs to know the exact count and needs to chelate with Iron chelators. In my opinion, Lipoic Acid is a supplement that can help but can NOT be used explicitly alone as a chelator.

Dori:

--- Quote from: Narendra on January 10, 2011, 05:34:06 PM ---Unless we know her exact ferritin levels, it is difficult to comment. Elevated levels of ferritin can be anything above the normal range. If her ferritin level is above normal, she needs to know the exact count and needs to chelate with Iron chelators. In my opinion, Lipoic Acid is a supplement that can help but can NOT be used explicitly alone as a chelator.

--- End quote ---

I was wrong. She has told me her ferritin level and it is 1200.

Narendra:
While her levels don't seem dangerously high, it might be a good idea to keep a tab on her ferritin levels and start chelation to maintain it to a safe value.

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