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Ferriprox absorption on transfusion day.

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cherieann:
I would have thought that with the extra iron from the transfusion, chelation would be very important.  :dunno
I can only stick to what I know and that is chelate whether I'm being transfused or not.

nice friend:
Well,
my Thal center stoped Patients to have chelation during Tx , the reason they gave when i asked was , it would be difficult to figure out to wat infection/reaction took place if you're having both (Desferal and Blood ) infusion at same time , but i argue, that i never had any reaction from Desferal soo let me have chelation , but they were stubborn but after that i discussed to thal center's doctor that i have to take  IV Desferal so allow me  .. and then she prescripted on my file and never argued again ..  they said desferal is 33% effective with blood and i said its better than nothing ... and i got permission ... now as usual i m having Desferal during chelation , and also Ferriprox tabs bfore going to center and offcourse Vit-E ... 

Best Regards
Take Care
Umair

SF:
Not sure about L1 or Exjade, but hematologists in US have now started recommending against taking Desferal with blood transfusions. I have been getting desferal on and off with transfusions. Since about 2 years, however, I have been stopped IV desferal with the blood transfusions. I believe the reason for doing so is more than just the affectiveness of the drug. It has to do with developing reactions and not knowing exactly whether the patient is reacting to blood or desferal.
I also vaguely remember my doc telling me about recent research showing some harm to cardiac muscle (perhaps absorbing more iron)  or to something else when desferal is infused alongside transfusion.

Like I said, I'm not sure about the 2nd reason I pointed out above. Perhaps other fellows who have been advised against taking desferal while being transfused can share why so? Perhaps Andy could also share his knowledge on this topic?

Regards,
SF

Annie:
hello.
My doctor also told me not to take desferal while bt,
i asked the reason but i could n't get it

nice friend:
For Complete Article, please visit :
http://www.drugs.com/mmx/deferoxamine-mesylate.html
Revised: 06/22/2000

--- Quote ---For chronic iron overload
The route of administration, either intramuscular or subcutaneous, must be individualized for each patient.

Because of the short serum half-life of deferoxamine, most of the drug may be rapidly excreted after a single intramuscular injection without binding any iron. However, continuous subcutaneous infusion may be almost as effective in mobilizing iron as continuous intravenous infusion. {19} Therefore, a small mechanical infusion pump may be used to administer deferoxamine into the subcutaneous tissue of the abdomen. Deferoxamine is then infused very slowly over 8 to 16 hours on an outpatient basis. {13} The duration of subcutaneous infusion with a portable mini-infusion pump must be individualized, depending on the rate of the patient's iron excretion. This regimen may remove 2 to 3 times more iron than a single daily intramuscular injection. {13}

Patients who do not tolerate deferoxamine therapy because of cutaneous pain and swelling or hives may receive the medication via an infusion pump in an indwelling central venous line at an adult dose of 2 to 4 grams (40 to 80 mg/kg of body weight) administered over 12 to 16 hours.

If a net negative iron balance in response to deferoxamine can be achieved, long-term therapy should be considered in patients with transfusional iron overload.

[bgcolor=#ffffff]If blood is transfused during deferoxamine therapy, it must not be mixed in the same container with deferoxamine.[/bgcolor]
Iron toxicity, chronic
Intramuscular, 500 mg to 1 gram a day.

Intravenous, [bgcolor=#ffffff]in addition to intramuscular administration, 2 grams infused at a rate not to exceed 15 mg per kg of body weight per hour. This is administered at the same time each unit of blood is transfused, but through a separate line.[/bgcolor]

Subcutaneous, 1 to 2 grams (20 to 40 mg per kg of body weight) a day administered over a period of eight to twenty-four hours by means of a portable, continuous mini-infusion pump
--- End quote ---

this study Revised on : 06/22/2000  ... old study but its the only research i found on internet about not  using desferal in same line ..... no details provided about the reason of this advise to not having desferal in the same line with blood ...

Best Regards
Take Care
Umairrrrr

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