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A breakthrough in the usage of Resveratrol

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JQP:
Regarding Professor Gambari answer vs. David Sinclair for Longevinex saying that Quercetin is essential to the effectiveness of the Longevinex in that it "...quercetin also helps to activate the same gene that resveratrol does, albeit less potently".  I thought Pro. Gambari said that quercetin inhibit the growth of HbF.  So if there are no HbF production doesn't that mean the present of resverotrol are minuscule to non?  See a thread I found below.  Maybe you could make sense of what they are trying to say.

QUOTE
"....Sinclair found that only research-grade resveratrol produced under hypoxic conditions and sealed under nitrogen during storage were found to have significant biological activity. The compound simply oxidizes rapidly... think of a sliced apple which turns brown after a short time. Longevinex is the first supplement to be produced under a nitrogen environment, and sealed in an air-tight capsule with a nitrogen bubble inside to protect from oxidation. For the same reason, the resveratrol in red wine is quickly oxidized in less than a day after the bottle is opened. Since wine can be purchased in the plastic collapsable bags, some have chosen to supplement with resveratrol in this fashion. However, one would have to drink over 10 glasses of typical red wine per day to get the same amount of resveratrol, if my memory serves; although some red wines contain more resveratrol than others.

Another problem with resveratrol is that it rapidly forms conjugates both in the digestive tract and during the initial pass through the liver. Quercetin can saturate and bind to the same compounds which conjugate with resveratrol, so Longevinex also includes quercetin in the pill. However, it is a small amount, and my guess is that all of the quercetin, plus all of the resveratrol in the pill will become conjugated. A possible solution to this is to take extra quercetin (say 500mg) shortly before taking Longevinex. Two published studies now have found that resveratrol rapidly forms conjugates and is likely not bioavailable. Quercetin is believed to inhibit this conjugation, and quercetin also helps to activate the same gene that resveratrol does, albeit less potently." 

Bigg:
But does this oxidized or conjugated resveratrol work as an antioxidant, or has it any effect on SIRT gene that is supposed to work like a low-calorie diet when activated by resveratrol? Maybe there is at least antioxidant effect when there is no fetal hb inducing effect (although I doubt it)?

green1706:
The most efficient way of administering resveratrol in humans appears to be buccal delivery, that is without swallowing, by direct absorption through the inside of the mouth. When one mg of resveratrol in 50 mL solution was retained in the mouth for one min before swallowing, 37 ng/ml of free resveratrol were measured in plasma two minutes later. This level of unchanged resveratrol in blood can only be achieved with 250 mg of resveratrol taken in a pill form.

 :wah

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