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Message from Professor Gambari to all thalpals

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nice friend:
Manal Sis ,
its weekend sis , thats why nobody at home , nobody is here ...hahah hahah hahaha ...... i think now everybody should have to adopt my way of getting replies , like i did for Blueberry's thread , yeah feedback like story and point the thread how important feedback is .... hahhahhaha lolzzz Sis ...

Best Regards hope that this thread will get reply, very soon ,

Umair

Andy Battaglia:
Manal,

To answer your questions.

1) The donor blood will have little if any fetal hemoglobin in it, so it will not affect the test results. Most people have close to zero HbF.
2) Transfusions suppress the bone marrow so the activity is lower (close to normal). This would make it hard to get much effect from taking fetal hemoglobin inducers. There will still be a minor effect but not enough to make much difference. This is one reason hydroxyurea has seldom been tested on majors in developed countries. It would require cessation of transfusions for several months to make the bone marrow active enough to get the maximum effect from the hydroxy.  Most well cared for patients are not willing to go through this drop in Hb to try hydroxy. This is also why the main research into hydroxy use in majors has taken place in countries where care is already lacking (ie. Algeria), and why hydroxyurea has been suggested as a possible therapy for majors in these countries.

Manal:
Thanks Umair  :wink

Thanks Andy, it is more clear now and makes alot of sense :wink

manal

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