Discussion Forums > Working Towards a Cure

Hydroxyurea Therapy in 49 Patients with Major Beta-Thalassemia

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cherieann:
Everybody is different so we react different. I did a trial and after 4 months, started extending transfusions. As my doctor said, it reacts differently. Some need a higher dose where some don't. Some will take time where other people, it won't work on.

Lena:
Of course, everyone is a specific individual case. I only refer to the results I am aware of.

Lena.

Andy Battaglia:
As Manal has previously pointed out, hydroxyurea does work better in people with certain genetic mutations, so this is one of the factors that affects the results.

baal:
hi andy

and witch mutation u mean?

u think i could give em a chance to risk it.....?

i have thebeta compound pluse the alpha trail...
                       
                                         panos

Andy Battaglia:
Panos,

Two thalassemia mutations that have been shown to have a better response to hydroxyurea are Xmn1 and IVSII-1. It has also been found that alpha deletions can add to the effect  in these beta mutations. Do you know which beta mutations you have?

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