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Transfusion Independence

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Dori:
I wished  that article would say to which level the ferritin had dropped before they saw a change. I am a negative person, therefore I do not believe it made them transfusion free. Doc could also decided to do not transfuse before there hgb hit 3mmol/l and some of use can manage not to let that happen.

ironjustice:

--- Quote from: ironjustice on October 28, 2010, 02:46:28 PM ---Restoration of Hematopoiesis After Iron Chelation Therapy
With Deferasirox in 2 Children With Severe Aplastic Anemia
--- End quote ---

Positive effects on hematopoiesis in patients with myelodysplastic syndrome receiving deferasirox as oral iron chelation therapy: A brief review.
Guariglia R, Martorelli MC, Villani O, Pietrantuono G, Mansueto G, D'Auria F, Grieco V, Bianchino G, Lerose R, Bochicchio GB, Musto P.
Leuk Res. 2010 Dec 22.
Department of Onco-Hematology, Centro di Riferimento Oncologico della Basilicata, IRCCS, Via San Pio 1, 85028 Rionero in Vulture (PZ), Italy.

Abstract
Iron overload is a frequent consequence in transfusion-dependent myelodysplastic syndromes (MDSs), which often requires iron chelation therapy (ICT). Interestingly, ICT may sometimes induce a hematologic improvement that leads to significant reduction or complete interruption of blood transfusions. This phenomenon has been recently described in MDS treated with the new oral chelator deferasirox. Here we briefly review the literature about this phenomenon and discuss the possible biological mechanisms underlying hematologic effects of deferasirox in MDS, starting from a new paradigmatic case in whom both hemoglobin level and platelet count improved, inducing transfusion-independence, soon after starting the treatment with deferasirox.

Copyright © 2010 Elsevier Ltd. All rights reserved.
PMID: 21185078

Dori:
Read my letters. Hepcidin is going to be the key to control iron. I dream about hepcidin in pill form. Ha!

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