Discussion Forums > Working Towards a Cure

Bluebird Bio gene therapy company

(1/3) > >>

7assan:
bluebird bio is the leading gene therapy company for the development of breakthrough treatments for severe genetic disorders. The company’s proprietary platform treats the cause of genetic diseases by placing a healthy gene into the patient's extracted bone marrow stem cells, and transplanting these corrected stem cells back into the patient. bluebird bio is conducting Phase I/II trials with its LentiGlobin™ product in Thalassemia, one of the most prevalent human genetic disorders. To date, all patients receiving the full therapy with both products have been cured and are healthy.  The company’s proprietary stem cell processing, GMP manufacturing and gene therapy vector technologies are also applicable to treating other genetic diseases. 
This is an exciting opportunity to join a privately held company working to identify novel therapies to treat rare genetic diseases.  You will work with leaders in field to discover and develop new therapies to treat debilitating diseases that have little or no treatment options available today. 

The successful candidate will participate in design and implementation of the establishment of viral vector producer lines, which includes molecular cloning, cell culture, titration, various immunological assays, flow cytometry and other related techniques.  Additionally, you will provide support in cell culture and gene transfection and detection, immunostaining, isotope labeling and detection, DNA/RNA purification and hybridization and qPCR.  You will be responsible for writing relevant technical reports and presenting research work as well as maintaining the virology and biosafety level II laboratory as a safe and organized working environment.


http://jobview.monster.com/Research-Associate-Vector-Biology-Job-Cambridge-MA-US-92035576.aspx

love and prayers:
i´m confused. successful gene therapy? 2 patıents cured?

ıs thıs true?

Andy Battaglia:
This is the same company yet again, formerly Genetix, but with a brand new name. They have had that same one patient success after failing with the first patient. I would like to quote Dr Persons comments on this so we can maintain some perspective.

http://www.medscape.com/viewarticle/728656  (it may be necessary to create a free Medscape account to view the article).


--- Quote ---"Whenever a hematologist or oncologist hears, in terms of your blood system, that one clone is that dominant, that frequent, that's usually associated with a bad thing. One [clone] shouldn't take over that much," said Derek A. Persons, MD, PhD, from the Department of Hematology and Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, in a telephone interview with Medscape Medical News. Dr. Persons also commented on the study in a News & Views article in Nature.

"But you've got to remember, it's still only 7% of all the [blood] cells in the body. And the key thing is that it stopped growing, it plateaued, and it stayed stable," said Dr. Persons. "Cancer doesn't stay stable, so this guy doesn't have cancer. He's got his clone, and we don't know what's going to happen to it. Like I said at the ending of the [News & Views article], the only way we're going to really ever know is, we watch him."
--- End quote ---

I'm going back to what I asked previously. How do they expect the FDA to ever approve a process that involves a mutated gene? How long do we have to watch this patient before we know for sure it is safe? And would not using a normal beta globin gene be preferable?

7assan:
Yeah but i think this gene therapy company have already cure  patient with thalassemia and thery are doing same thing with other 10 patient and FDA have approved , so wht is porb with this company , finenac or wht ......or this comapny is fake wht is this compay story .....we want to know .......?

Andy Battaglia:
This is the same story that has been posted here many times. They have managed tremendous media coverage from one case. But please keep in mind that others like Dr Sadelain and Dr Persons are both carrying on separate gene therapy research. Dr Sadelain will speak tomorrow and I am anxiously awaiting his message. His 10 patients who are ready to start trials are in no way related to anything Bluebird Bio is working on.

Navigation

[0] Message Index

[#] Next page