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Researchers Model Fetal-to-Adult Hemoglobin Switching

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love and prayers:
Asa,
i got in touch with a team member of the research  'KLF1 regulates BCL11A expression and [gamma]- to [beta]-globin gene switching'

  We are now searching for small molecules that will down-regulate KLF1 and BCL11A and therefore up-regulate fetal hemoglobin.  After we identify a specific small molecule and prove that it is safe and effective in our mouse models of sickle cell disease and b-thal, we will plan a clinical trial.

I would be happy to update you on our progress.  The best way to receive an update is for you to email me in about 6 months.  We are probably 2-3 years away from a clinical trial.

All the best/  Tim

love and prayers:
http://www.ithanet.eu/archives/1735

The Community Portal for Thalassaemia and other Haemoglobinopathies
News
EKLF/KLF1 Multicenter Study
February 10th, 2011 2 comments

The ITHANET network is hosting a collaborative project intended to map KLF1 mutations and HbF levels including the Gγ ratio. We would like to invite your participation in this project. Details of the study can be found here.
...

Hi. Im Joseph Borg, one of the leading co-ordinators for this collaborative project. In order to fully explain the details of this project., can you kindly contact me by sending me an email on joseph.borg@biotech.um.edu.mt

Thanks, and looking very forward to your reply.

best

Joseph

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