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hydroxyurea

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POAR:
Andy,
My son is having E-Beta Thal, got detected in 6months of age. He is now 2.5 years, under regular transfusion of around every 4 weeks. We have checked with our Dr in Bangalore about starting HU on him. Dr is not very eager to start it as his experience of HU on E-Beta thal is not great.  I want to check your thought about this drug on E-Beta.

surendra:
Hi Andy
my daughter is taking hydroxyurea (500mg alternate day) since last 3 months. Last week on 30th august her Hb was 9.2 and today on 7th september it was 7.1.  How can it be possible???   And this is not the one time, The same thing happened in the last two months also.
In the last month her Hb was 10.1 at the time and after two weeks it was 6.9.  We couldn't understand. In these days she has no fever and no any kind of infection. She is active  and eating properly. The main problem is fast decrease of Hb level without any reason.

Andy Battaglia:
Surendra,

Has she had any transfusions during this period?

surendra:
Yes Andy
when her Hb level was below 7 she had transfusions. She is getting transfusion every month after using hydroxyurea.

surendra:
Hb decreases fast in last few days(2 points in a week). Is this normal when using hydroxyurea????

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