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hydroxyurea

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Andy Battaglia:
I would think the drop in Hb is related to antibody reactions and has nothing to do with hydroxyurea.

surendra:
Thanks Andy
why this antibody reaction happened every month(specially in last week) ?? and we are using leukocyte filter during transfusion every month. Could u please tell me the reason of this reaction???
What I observed that first three weeks after transfusion her hb drops only 1-2 points and after this it drops very quickly (almost 2 points in a week). 

Andy Battaglia:
If it only happens at the end of the transfusion cycle, it is simply the transfused blood breaking down. This is normal. The only thing that may make it last a bit longer is using fresh blood, which in most cases means arranging a group of regular donors, so that the blood is always newly drawn from the donor. Electrophoresis should be done to see if the HbF level is increasing, as it is the method to determine if the hydroxyurea is having any impact.

surendra:
Yes Andy We have arranged some donors who donate blood a day before transfusion which means it is always fresh blood to give her. It is continue since a year.  So that antibody reactions should minimize.
Definitely we will do Hb electrophoresis test in next month before transfusion.
I want to share one thing that her Hb goes down but her activities become normal. We can't recognize  that her Hb is so low.

catchR:
Hi Surendra,
Hope you are still continuing with HU for your little one. Just wanted to know your experience with HU and if there is any positive indications (raise in Hb-F in total Hb) and increase in transfusion intervals.

Wanted to check this as my little one is just over 2.5 yrs and was looking into the possibility of starting HU for her. Also, wanted to know other's experience as well with HU.

Kindly advice, thanks!!

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