Discussion Forums > Thalassemia Major

Tiredness and Low HB

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Andy Battaglia:
It's very simple. The classification of thal intermedia is what causes the confusion. If a splenectomy can mostly eliminate transfusions, the patient is a transfusing intermedia (that is a very vague category). Many patients are diagnosed as majors because they require transfusions, but unlike a major, if they did not transfuse, their Hb level would still be high enough to survive, although with rather bad health. A true major would die if transfusions were stopped. This is actually very common because once a patient takes regular transfusions, many doctors will classify that patient as major, even though technically, their genotype would show intermedia. While a major might see some reduction in transfusion requirement after a splenectomy, it would not eliminate this need, as it can for many intermedia patients.

fifififi:
Yeah, i've been diagnosed as thal major since i was a baby.. A miracle, if i could say bcause after i had my splenectomy, i still hv another spleen (accessoris) , and bfore i had my surgery, the doctor didnt even know that i hv 2 spleens.. It is a miracle.. But, can thal major be a thal intermedia or what? I also didnt understand well about that..

Pratik:

--- Quote from: fifififi on January 23, 2013, 02:50:06 AM ---Yeah, i've been diagnosed as thal major since i was a baby.. A miracle, if i could say bcause after i had my splenectomy, i still hv another spleen (accessoris) , and bfore i had my surgery, the doctor didnt even know that i hv 2 spleens.. It is a miracle.. But, can thal major be a thal intermedia or what? I also didnt understand well about that..

--- End quote ---
You most likely have thal intermedia but were classified as major because of frequent required transfusions if I understood Andy correctly.

-P.

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