Discussion Forums > Working Towards a Cure

Update on Gene Therapy and Debate about Myelosuppression vs Myeloablation

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diab:
Hey Andy,

I add my voice to yours as well, the approach you proposed sounds more reliable and promising.

I have some questions:
1) How old your first patients are?
2) Is Gene therapy going to be implemented successfully on Adult patients (30+) ?

I would like to hear if their is any research group in this planet that is researching curing Thal for adults.

All the best.

Pratik:

--- Quote from: diab on March 28, 2013, 03:37:45 PM ---Hey Andy,

I add my voice to yours as well, the approach you proposed sounds more reliable and promising.

I have some questions:
1) How old your first patients are?
2) Is Gene therapy going to be implemented successfully on Adult patients (30+) ?

I would like to hear if their is any research group in this planet that is researching curing Thal for adults.

All the best.

--- End quote ---
The first patient (female) is 27 years old I think.

Andy Battaglia:
I do not have any information on the patients, as it is confidential. They are only taking adults who meet the criteria for the trial. It is expected that this will work on all ages, as there is not the rejection that occurs with BMT.
By the end of 2013, we will know a lot about this trial.

Andy Battaglia:
I heard from Pat G this week and after meeting with Dr Sadelain, Pat says they feel this debate is over and that myelosuppression is sufficient, making this procedure much easier on patients. This is monumental for patients. The gene expression is happening faster than they thought it would and the chemo regimen is enough without being too much.

Participation in trials by the eligible should be considered.

Sushil:
Hi Andy,

I agree with the milestone, Myelosuppression of bone marrow is more logical approach, why give chemo more than it require. Btw do you have any update on other people trial also , you mentioned that second patient will be beginning in Feb and another one in May.

we need to see every update carefully as Gene therapy is not a medical practice its a reasearch which will be base for medical practice in future.

Regards
Sushil Thakur

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