Discussion Forums > Thalassemia Major
Liver levels and exjade
Hamdan:
My wife is on desfiral for about 25 years as she is thal patient, she got Hep-C 3years ago, now her ferritin increased 4400 so I read about Exjade, so please my question is: does Exjade effects liver functions? Is it ok to use for Hep-c instead of desfiral ?
Thanks
Poirot:
--- Quote from: Hamdan on September 25, 2013, 04:09:41 AM ---My wife is on desfiral for about 25 years as she is thal patient, she got Hep-C 3years ago, now her ferritin increased 4400 so I read about Exjade, so please my question is: does Exjade effects liver functions? Is it ok to use for Hep-c instead of desfiral ?
Thanks
--- End quote ---
Is L1/Ferriprox an option for you? In general, L1 does not affect liver or kidney functions and has worked quite well in lowering iron concentrations in thals with hep C.
Poirot
Hamdan:
Hi Poirot,
I am new here and I didn't hear about L1/Ferriprox before, by the way we visited my wife's Dr today and when I asked her about Exjade she said it has no side effect on Liver for Hep-c !! I am so confused and I really need help on that as I can read that Exjade increasing Alt and my wife already has High Alt (165) So will we start with Exjade as Dr recommend or we stick to Desfiral ?????! Or we try your option L1/Ferriprox???
I will appreciate all your help
Poirot:
Dear Hamdan,
Where are you based?
Your doctor is correct insofar that Exjade is NOT contra indicated for Hep C infection. However, from a practical standpoint that is of little use as you don't want your liver to be affected by something else, when it is already battling Hep C.
Given that Exjade does not affect everyone equally, you could give it a trial and see if it further raises liver enzyme levels - if it does, then stop. If not, then you are set.
Ferripox is available globally now - so, you can ask your doctor about it.
Cheers
Poirot
Hamdan:
Dear Poirot,
Thank you so much for your advise, We are from Egypt, Cairo.
I will talk to her Dr about Ferripox but as you said we can give a try for Exjade as I read here it's so good, Now I want to ask you, I know that Exjade recommended dose for High Ferrtin is 30m/kg, my wife is 62KG so she should take about 2g daily of Exjade! but for some financial issues her Dr. said we can take 1g daily ( 2 bills X 500mg ) along with 1500-2000 mg Desfiral 3/4 days a week, is that good enough to work with here ferrtin high levels (4400)??
I will be waiting for your good advise
Thanks
Hamdan
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