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hydroxyurea , why not recommended ?

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Andy Battaglia:
I may be very busy a lot of the time, but I am never bored. Persevere with your doctor. Your child deserves a chance to try this drug. If you are allowed to use, talk to me before starting. Wheatgrass should be taken with it. In fact, even if you can't get approval, wheatgrass tablets would be advised, anyway.

gabriellavanessa:
Hi andy,

sorry again,asking help. I just back from doctor, try to find the doctor who can supervise hydroxyurea.  I lost my paper which contain information what should we care in blood test during the treatment. I get the this website from this forum you post, but i want to print again, i cannot find it. Can u give that link again ?

tahnks
lucky

gabriellavanessa:
Hi Andy,

after see so many doctor in jakarta, indonesia. yesterday, i just make appointment with other hematologist doctor, more logical explanation. She tell me why hydroxyurea is not use in asia, cause pattern of dna , asian thal dna, is not same with india and europe. so useless to try. She said, my child is double heterozigot mutation HbE and Condon 41-42. Condon 41-42, it's mean cannot produce HbA. What is meaning of mutation of condon 41-42 ??

Is this true ? or any body , have mutation condon 41-42 try hydroxyurea and success ?

thanks
lucky

Andy Battaglia:
Codon 41-42 (-TTCT); TTCTTT) is the specific beta mutation.

Many HbE beta thal patients respond well to hydroxyurea. Every single study on hydroxyurea comes away with the same conclusion. The specific thal mutation present is not a good indicator of whether or not hydroxyurea will work on a patient and that in the end, the only way to tell is to try this very safe drug.

Your doctor is being arrogant and stubborn and is basing opposition to use of this drug on nothing more than arrogance. I do not know how you can change the mind of a doctor who prefers arrogant ignorance. There is not a single doctor on earth who can tell you that this drug won't work without having tried it.

gabriellavanessa:
hi andy,

thanks andy, i will find the doctor , who can minotor my child. fyi, next step , we will go to thailand , to make appointment with Dr. Suradaj, at Mahidol Hospital. I Will ask the doctor in thailand to try hydroxyurea

thanks
lucky

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