Discussion Forums > Thalassemia Major

Jaakafi

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djema:
Hello friends and Andy .
In Russia, we offer the cure Jakavi.
What would You advise ? Many thalassemia patients are taking this medication ?
In Russia box Jakavi is red and firm Novartis produces Jakavi in blue color???????? :-\


 

Andy Battaglia:
Jakavi is a JAK2 inhibitor that is available for some other conditions in the US, but phase 3 trials for use in thalassemia has just recently concluded. The drug reduces spleen size and a slight increase in pre-transfusion Hb was also noted during trials. The hopes are that this drug will be an alternative to splenectomy. This may be especially helpful to the many patients who experience regular periods of hemolysis, requiring more frequent transfusions.

Do you know people using the drug and what their results have been?

Hafiz Akhtar:
Andy, Is JAK2 only available in US or in some other countries also. can it be availed easily from Markets in US. thanks

Andy Battaglia:
I know very little about this drug. It is approved for other conditions, but the report on the trials for thal was just submitted in December, 2016. I would like to know more about how it is being used and what the results have been, but I am still waiting for a reply from djema.
This is the link to the trial report. http://www.bloodjournal.org/content/128/22/852?sso-checked=true

What seems most important is that for the spleen size to shrink, ineffective erythropoiesis in the bone marrow would have to also be reduced. This is one of the two goals of transfusion, so that would have dramatic effects on the health of the patient taking this drug.

djema:
 :rolleyesFriends ,I apologize for the late response .
I will try to gather more information about Jakavi , my friends from Dagestan not long ago started to take this drug .

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