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COVID-19, is iron overload a relief?

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jay:
Hello All,

It has been long since I was here. Miss you.
I came to see if someone has already raised this up and check for information and guidance.

It looks from initial studies (non-peer reviewed?) that SARS-CoV-2 molecule has some affinity towards heme.
Suggestions of hypoxia before lung failure due to knocking off iron from heme by the Virus.

I am not able to comprehend if that’s a relief OR a concern.
Jay has very good ferritin numbers ~300. We make on/off decision at around 400 desferal+ferriprox(liquid) [It’s not the dosage its the continuity]

Would it be recommended to stop chelation for adequately chelated thal at least for a while now. Does it make sense to think virus molecule will react with free iron.
What about elderly thal-minor, should transfusion be considered well within time after hospitalization because of COVID-19.

There is observation suggesting anemia is a factor in loss form this disease but is that really related to heme vs the virus.
Trials are going on all over for Hydroxychloroquine. Hydroxychloroquine-Malaria, Maleria-Thal is there any actual relation or is this effects of watching house md and the knick ..

References:
https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin/11938173
https://twitter.com/davidasinclair/status/1238972087395659778?s=19

Stay Home, stay safe and keep homes adequately humid (40-60).

jay:
EMedTox has raised n number of questions.
https://twitter.com/emedtox?s=09

jay:
I am pressing a panic button here, the information is growing on me very fast.

https://www.sicklecellsociety.org/coronavirus-and-scd/

Shielding! Extremely vulnerable group!! This is full blown alarm!!!

Take care buddies.

jay:
How did I miss this information on organisations front pages.

https://www.thalassemia.org/covid-19-resources-for-people-with-thalassemia/

https://thalassaemia.org.cy

Andy Battaglia:
My interpretation of the study you mentioned would show this is less of a threat to thals, because the higher the Hb, the more likely one is to have serious consequences from Covid. Thals, with their lower Hb would be less affected, if that study's results are correct. Most other "studies" I have seen on what Covid does have been guess work.

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