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Pyruvate Kinase Activation

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ironjustice:
Would this give credence to the theory of iron, before, the manifestation of Thalassemia?
Since iron inhibits pyruvate kinase?

The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model
https://pubmed.ncbi.nlm.nih.gov/33822774/


Iron-Dependent Oxidative Inactivation with Affinity Cleavage of Pyruvate Kinase.
https://link.springer.com/article/10.1007/s12011-009-8317-x

raziqrazac:
This looks interesting. Is this treatment in the market now ?

Andy Battaglia:
It was just approved in the US in February, 2022.
http://drugapprovalsint.com/mitapivat/


--- Quote ---On February 17, 2022, the FDA approved mitapivat as the first disease-modifying treatment for hemolytic anemia in adults with pyruvate kinase (PK) deficiency, a rare, inherited disorder leading to lifelong hemolytic anemia.6 Mitapivat has also been investigated in other hereditary red blood cell disorders associated with hemolytic anemia, such as sickle cell disease and alpha- and beta-thalassemia.1
--- End quote ---

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