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Apoptosis & L-Carnitine

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Manal:
Hi,

From the first day my son was diagnoised, his hema. prescribed him the L-Carnitine oral drops that were given twice daily for the first month and then twice 5 days in the week forever. Actually, i just thought that it boosts all the body muscles and enhanced the activity ,but i read a study (by the way my son's hema participated in this study) that made me understand what it really does.

It was found that L-Carnitine reduces apoptosis in many diseases such as thal.
http://www.medterms.com/script/main/art.asp?articlekey=11287


--- Quote ---Apoptosis: A form of cell death in which a programmed sequence of events leads to the elimination of cells without releasing harmful substances into the surrounding area. Apoptosis plays a crucial role in developing and maintaining health by eliminating old cells, unnecessary cells, and unhealthy cells. The human body replaces perhaps a million cells a second. Too little or too much apoptosis plays a role in a great many diseases. When programmed cell death does not work right, cells that should be eliminated may hang around and become immortal. For example, in cancer and leukemia. When apoptosis works overly well, it kills too many cells and inflicts grave tissue damage. This is the case in strokes and neurodegenerative disorders such as Alzheimer, Huntington and Parkinson diseases. Apoptosis is also called programmed cell death or cell suicide. Strictly speaking, the term apoptosis refers only to the structural changes cells go through, and programmed cell death refers to the complete underlying process, but the terms are often used interchangeably
--- End quote ---

Apoptosis also can cause heart failure
http://www.medicinenet.com/script/main/art.asp?articlekey=565


--- Quote ---Researchers in Boston recently examined hearts obtained during heart transplantation. The hearts from patients with cardiomyopathy demonstrated the characteristic features of apoptosis. These results, reported in the New England Journal of Medicine (1996;335:1182-9), support the concept that programmed cell death plays a role in leading to end-stage heart failure.
--- End quote ---

So the study they made showed that L-Carnitne helps in reducing apoptosis in thal
http://content.karger.com/ProdukteDB/produkte.asp?Doi=87890

 
--- Quote ---Conclusion:L-Carnitine seems to be a good modulator of apoptotic processes in thalassemic patients leading to a decreased frequency of programmed erythroblast death and general improvement of the disease condition.
--- End quote ---

I thought this information could be of any help

Take care
Manal

§ãJ¡Ð ساجد:
Thanks for sharing this info Manal,

It is very interesting indeed.

Take care, Peace!

jzd24:
Manal,
     You never stop researching and sharing things that will help your son and others. You are great! Jean

Sharmin:
Thanks Manal,

You are the best  :hugfriend.  I hope your kids are well  :love

Would L-Carnitine be helpful to thal majors as well?  Andy, do you have any thoughts on this?

Sharmin

Manal:
You are welcomed Sajid, i am happy you found it interesting :wink


Jean, thanks for the compliments :hugfriend. If you find anything good, it is because of you and each member in this forum  :grouphugwho give a lot of inspiration and hope that there will be a cure, so until then we have nothing but to search and search :tired and share whatever we find useful.


Sharmin, you are welcomed and thanks for the compliment. Speaking of the best , i guess it is you :thumbsup because you are one of the great moms who was able to change a really difficult and hard disease( in all terms) like  thalassemia to something ''nice'' and ''smooth'' that your son is ''enjoying'' and coping with. I guess i will be in need of a lot of advices and strategies because Ahmad is really giving me a hard time (not the attitude of crying,but his depression since he is the only one in the family who is always poked with needles) with every needle he gets. :nurse

Anyway, back to L-Carnitine, the study was made on thal major children from the age of 6.6 to 12.2 years.


--- Quote ---We investigated the effect of oral L-carnitine therapy on apoptosis in thalassemia major patients. Methods: Eighteen thalassemia major patients with a mean age of 12.2 ± 6.6 years were included
--- End quote ---

Love to you all :love

Manal

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