Thalassemia Patients and Friends
Discussion Forums => Working Towards a Cure => Topic started by: Andy Battaglia on May 28, 2011, 07:07:27 PM
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http://informahealthcare.com/doi/abs/10.3109/03630269.2010.513638
Red blood cells (RBC) and reticulocyte parameters were determined on peripheral blood from a subset of patients enrolled in the multicenter study of hydroxyuea (HU) in sickle cell anemia. Multiple blood samples were obtained every 2 weeks. Cellular indices were measured by flow cytometry. Generalized linear models were used to determine the relationship between the longitudinal trajectories of RBC and reticulocyte indices and HU usage. There was a significant relationship between HU usage and most of the RBC and reticulocyte indices. Hydroxyurea produced higher value trajectories than those generated by placebo usage for the hemoglobin (Hb) content of both the RBCs and reticulocytes and for the mean corpuscular volume (MCV) of reticulocytes. These changes were first detected 10 weeks after starting HU and before the increase in Hb F levels. The data suggest that subtle and early markers of response to HU reside in the hemogram.
Read More: http://informahealthcare.com/doi/abs/10.3109/03630269.2010.513638
This was a study of sickle cell patients, but should also be applicable to thalassemia. These early tests are good indicators of the usefulness of hydroxyurea in thal patients, also.
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Yes this is exactly what happened to us from the first month of using hydrea. Increase in MCV and hematocrit and decrease in the reticulocyte counts
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New Hydroxyurea study in the United States
http://www.bioportfolio.com/resources/trial/127084/Hydroxyurea-to-Treat-Beta-Thalassemia-Cooleys-Anemia.html
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But it do not show the results... ???