Thalassemia Patients and Friends

Discussion Forums => Thalassemia-related Issues => Topic started by: jatin on August 22, 2018, 12:24:42 PM

Title: Test for early daignoss of cardiac problems
Post by: jatin on August 22, 2018, 12:24:42 PM

Hello all pls suggest test for early daignoss of cardiac problem in Thalassemia major with severe iron overload.
As 2 D echo can't help much .
Our cardialogist are not trained for cardaic problem in thalassemia major .pls suggest what's are test should be done if t 2 * MRI is less than 8 ms .
Ferritin is more than 2500

Title: Re: Test for early daignoss of cardiac problems
Post by: Andy Battaglia on August 25, 2018, 07:14:11 PM

Jatin, in addition to the MUGA scan we discussed on Facebook, there is tissue Doppler imaging (TDI).

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900296/

Quote

Cardiac complications are among the most serious complications in Beta Thalassemia Major Patients. Our aim was to evaluate the value of tissue Doppler imaging (TDI) for early detection of myocardial dysfunction in pediatric and adolescent patients with B-TM before development of overt heart failure or cardiomyopathy...
Conclusion
Clinically asymptomatic thalassemic children and adolescents who had normal global functions by conventional echo-Doppler were found to have abnormal left ventricular and right ventricular dysfunctions detected by TDI. TDI is superior to Echo-Doppler in detection of early myocardial damage in asymptomatic thalassaemic patients.

Title: Re: Test for early daignoss of cardiac problems
Post by: jatin on August 26, 2018, 06:34:48 AM

Thanks Andy sir for you prompt reply.
I am confused between this test which should be done or all test should be done .
1) Tissue Doppler
2) Muga Scan
3 CMri.
Which one is best .
Thanks a lot

Title: Re: Test for early daignoss of cardiac problems
Post by: Andy Battaglia on September 01, 2018, 04:59:01 PM

I believe the tissue Doppler will give you the information you are looking for.