Thalassemia Patients and Friends

Discussion Forums => Thalassemia Intermedia => Topic started by: Nanami on March 26, 2022, 12:42:17 PM

Title: Alpha Thalassemia trait with low HB 8 or intermedia?
Post by: Nanami on March 26, 2022, 12:42:17 PM

My nephew who is 15 months just have his blood tested.
The result is

WBC.                9.3
RBC.                 5.4
Hemoglobin       79
Hematocrit.       22.6
MCV.                 42
MCH.                 14.7
MCHC.               35
Platelets.           404
MPV.                 9.9
RDW.                23.9

Differential White Cell Count

Neutrophils.        2.2
Lymphocytes.      6
Eosinophils.         0.4
Monocytes.          0.7
Basophils.            0

Calcium.              9.3
Iron/Fer.              43.8
CRP ( C-reactive protein).       9.8

Ferritin.             197.4

This is his Hemoglobin Electrophoresis Result

Hb H.                      0.0
Hb Bart’s.                1.2
Hb A.                      96.6
Hb F.                       0.5
Hb D-Punjab.           0.0
Hb S.                      0.0
Hb E.                      0.0
Hb A2.                    1.7
Hb CS.                    0.0
Degrade Hb.            0.0
Other Hb.           

What is the types of Thalassemia he got?
Is this Alpha thalassemia trait or HBH disease ?

His father has Alpha Thalassemia trait.
His mother doesn’t have Alpha or Beta Thalassemia trait ( but not sure if she is a silent carrier)
Is it possible that he has both Alpha Thalassemia trait with Beta Thalassemia silent carrier? ( because his HB is too low for Alpha Thalassemia trait )

Thank you

Title: Re: Alpha Thalassemia trait with low HB 8 or intermedia?
Post by: Andy Battaglia on April 06, 2022, 11:54:21 PM

The normal HbA percentage would suggest that this is alpha minor. The low Hb level is troubling. How is the child's health?
A DNA analysis could verify the specific type of alpha thal that is present.

Title: Re: Alpha Thalassemia trait with low HB 8 or intermedia?
Post by: Nanami on April 07, 2022, 12:44:45 PM

Thanks Andy for your reply. He is healthy and very active, but he is a little pale and underweight ( nearly 16months old) about 9.5kg, and his head is a little bit small.

I am very confused about DNA analysis for Thalassemia.
- Does he have to do both DNA analysis tests like one for Beta Thalassemia and other for Alpha Thalassemia?
- Or just one single DNA analysis test can show the abnormalities of both beta and alpha-globin ?

I am afraid that he is carried both Beta and Alpha Thalassemia.

Thank you.

Title: Re: Alpha Thalassemia trait with low HB 8 or intermedia?
Post by: Andy Battaglia on September 03, 2022, 07:35:47 PM

The DNA tests for alpha and beta are separate tests.