Thalassemia Patients and Friends
Discussion Forums => Announcements => Topic started by: bolu on April 26, 2012, 03:53:48 AM
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Hello dear friends,
I was newly diagnosed as a alpha-thalassemia minor carrier, --SEA.
So far I have no symptoms. But I don't know how this disease will develop. The doctors just say "No problem, you can live just like a normal person". Is that true?
I have read here so many friends complain about their problems as a tha. minor. I worried a lot. I don't know these friends are alpha-thal. minor or beta-thal. minor.
Has anybody any experience of alpha-thalssemia minor?
Does alpha-thal. minor share the same symptoms as beta-thal. minor?
I hope some friends may give me a help. :wah
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Hi Bolu,
Do you have any other blood work results from a CBC (Complete blood count)? Do you have any symptoms of anemia? Has the father been tested for being a thal carrier? Being a carrier is typically not a serious thing, but I would like to see some other test results to confirm that this is no more than the alpha mutation. It's not a big deal if the baby is a carrier, as long as there is no thalassemia gene from the father, also.
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Thank you, Andy!
I am so glad to hear you!
The father of my baby is complete normal, without Thalassmia.
My blood check result is as the following:
Code Rresult Unit Ref.
WBC 5.0 10¬¬9 / L 3.5 – 9.7
LYM#1 1.4 10¬¬9 / L 1.0 – 4.5
MID1 1.1 ↑ 10¬¬9 / L 0.2 – 0.7
GRAN1 2.5 10¬¬9 / L 1.8 – 6.4
LY%1 28.0 % 20 – 50
MID%1 22.0 ↑ % 5 - 12
GR%1 50.0 % 50 - 70
RBC 5.11 ↑ 10¬¬12 / L 3.5 – 5.0 female
HGB 106 ↓ g / L 110 - 150 female
HCT1 36 % 35 – 45 female
MCV 70 ↓ fL 80 - 98
MCH 20.7 ↓ pg 27 - 32
MCHC 294 ↓ g / L 320 - 360
RDW - CV 15.4 ↑ % 10.1 - 15
PLT 181 10¬¬9 / L 100 - 400
MPV 10.7 fL 6.5 – 12.5
PDW1 19.2 ↑ fL 15.5 – 18.1
PCT1 1.93 ‰ 1.0 – 2.8
GPD 1.7 1.0 – 2.3
HB1 No abnomal observed
HBF 0.2 ﹤2%
HBA2 2.4000 % 2 - 4
ROFT red cell osmotic fragility test positive
Result
Alpha-Thalassemia Genes Deletion Analysis -- SEA
Alpha-Thalassemia Genes Mutation Analysis Not seen
Beta-Thalassemia Genes Mutation Analysis Not seen
Analyses of Alpha Thalassemia Genes: --SEA, -a3.7, -a4.2, HbCS, HbQS, HbWS
Analyses of Beta Thalassemia Genes: 41-42, 654, -28, 71-72, 17, β E, 31, 43, -32, 27/28, -29, -30, 14-15, CAP, Int, Ivsl-1, Ivsl-5
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There are a total of 4 alpha genes on 2 chromosomes. With the SEA deletion, one set of genes doesn't work. But the other set of genes works normally. This is called alpha trait and is not a dangerous condition at all. It means you will have a mild anemia, but nothing worse. It also means that this is the most your child can have because the father isn't a carrier. Your child will either be an alpha trait like you, or not a carrier at all. Nothing worse is possible, so please relax. The doctor was right that it isn't a big deal to be an alpha carrier. The only concern is when two alpha carriers have a child together, because a severe condition can result. But as long as only one parent is a carrier, there is no danger.
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Thank you very much!