Prevlence of anti-HAV antibodies in multitransfused patient with beta-thalasemia

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Ahum..... Ahumm.... An article to break, please anyone break the article ..... i like to share this bcoze its related to the Anti-bodies .. i think it would be sharmin's topic of interest, mayb i  m wrong , but i want it to share , so i shared it ... i think its related to the Hemolysis or something .. i dont know ... to read complete article , here's the link ...

Link :
Prevalence of anti-HAV antibodies in multitransfused patients with beta-thalassemia

AIM: To detect the prevalence of anti-HAV IgG antibodies in adult multitransfused beta-thalassemic patients.


METHODS: We studied 182 adult beta-thalassemic patients and 209 controls matched for age and sex from the same geographic area, at the same time. Anti-HAV IgG antibodies, viral markers of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection were evaluated.


RESULTS: Anti-HAV IgG antibodies were detected more frequently in thalassemic patients (133/182; 73.1%) than in healthy controls (38/209; 18.2%, P < 0.0005). When we retrospectively evaluated the prevalence of anti-HAV IgG antibodies in 176/182 (96.7%) thalassemic patients, whose medical history was available for the previous ten years, it was found that 83 (47.2%) of them were continuously anti-HAV IgG positive, 16 (9.1%) acquired anti-HAV IgG antibody during the previous ten years, 49 (27.8%) presented anti-HAV positivity intermittently and 28 (15.9%) were anti-HAV negative continuously.


CONCLUSION: Multitransfused adult beta-thalassemic patients present higher frequency of anti-HAV IgG antibodies than normal population of the same geographic area. This difference is difficult to explain, but it can be attributed to the higher vulnerability of thalassemics to HAV infection and to passive transfer of anti-HAV antibodies by blood transfusions.
Liver disease in thalassemic patients
Seventy-six thalassemic patients (41.2%) were anti-hepatitis C virus (anti-HCV) positive, while 44 (24.2%) of them were also HCV RNA positive. None of them was HBsAg positive. Anti-HBc antibody was found in 56/182 (30.8%) of them.

Comparison of anti-HAV positive and anti-HAV negative thalassemic patients
When anti-HAV positive (n = 133) were compared to anti-HAV negative (n = 49) thalassemic patients (Table 2) there was no difference in age, sex or duration of transfusion therapy. Anti-HAV positive patients had received more transfusions than anti-HAV negative thalassemics P = 0.02). We also found that anti-HAV (+) thalassemics had lower frequency of previous splenectomy, although this difference did not achieve statistical significance (35.3% vs 51%, P = 0.055). An unexpected finding was that anti-HAV (+) thalassemics presented lower mean serum levels of aminotransferases (AST, P < 0.001; ALT, P = 0.039) and albumin (P = 0.025) than anti-HAV (-) patients. No statistical difference was found in ferritin values between these two groups. Patients with antibodies to HAV were also more frequently positive for HCV markers although this difference was not statistically significant.

Andy, Sharmin, Manal, Zaini and all other , please interpret the article ..

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Sometimes , He takes everything away from us so we can learn the value of everything we have.



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