B THALASSAEMIA (THALASSAEMIA MINOR) + HETEROZYGOU FOR HB – D (HBD 24.3%) = ?

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DEAR SIR,

I AM PREGNANT WITH 4 MONTH PERIOD, I AM  MINOR THALASSAEMIA  MY HAEMOGLOBIN ELECTROPHPRESIS TEST REPORT IT IS AS UNDER:

FOETAL HAEMOGLOBIN                       : 0.6%

HAEMOGLOBIN ELECTROPHORESIS   : A+A2 PATTERN SEEN

HAEMOGLOBIN A2 FRACTION            : 5.0%
(COLUMN CHROMATGRAPHY)

ABNORMAL HAEMOGLOBIN               : ABSENT

SICKLE CELL TEST                                   : NEGATIVE


IMPRESSION                                         : B THALASSAEMIA  (THALASSAEMIA MINOR)

AND MY HUSBAND’ S HAEMOGLOBIN ELECTROPHPRESIS TEST REPORT IT IS AS UNDER :
TYPE OF HB                             RESULT                         NORMAL VALUE

HB    -      F %                :        0.8                               LESS THAN 2.0
 
HB    -      A2 %              :        2.1                               LESS THAN 3.5
 
HB    -      D                    :        24.30                           NOT DETECTABLE

HB    -      S                    :       NOT DETECTED               NOT DETECTABLE

HB    -      C                    :       NOT DETECTED               NOT DETECTABLE

RETICULOCYTE               :       0.8%

SICKLING PHENOMENON   :       NEGATIVE

OTHER ABNORMALITY     :        -------------

IMPRESSION                   :      HETEROZYGOUS    FOR HB – D

NOW SIR ADVICE ME THAT ON THE BASIS OF THE ABOVEMENTIONED REPORTS IS THERE ANY POSSIBILITY THAT OUR NEW BORN CHILD WILL HAVE THAL MAJOR/ INTERMEDIA.

NOW HERE I WOULD LIKE TO KNOW HOW MUCH IS THE PERCENTAGE THAT OUR NEW BORN CHILD WILL HAVE THAL MINOR/MAJOR/INTERMEDIA

IS THERE ANY TEST,WHICH CAN DETERMINE THIS?

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Offline Cari

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As andy mentioned because u have have a trait and your husband does not your baby will not have thal major. There is a possibility that the baby can have thal minor like you but that isn't something I would recommend testing for.  Someone can correct me if my info is incorrect based on your results. Tc!

here in india, i did the genetic counsilling at Institute of Human Genetics ( Satellite
Ahmedabad, Gujarat 380015,they are  saying that because my husband is deteced hbd and hbd is also a form of thal minorl, and if hbd of my husband goes to my new born than thal major/minor in new born will depend upon the percentage of hbd gene like my husband has 24.8%therefore i should go for the CHORIONIC VILLUS or AMNIOTIC TEST.

THATS WHY I AM VERY MUCH CONFUSED  SO PLEASE  LET ME KNOW IS IT ALL TRUE ?
« Last Edit: May 25, 2011, 07:18:25 AM by heena »

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Offline Cari

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Well if u want to be sure, do the testing. Either test is fine to do now days. Just go to a skilled doctor. Ask them how many cvs tests they have performed. I think the cvs is better because u get the results earlier. The risks are supposed to be higher but recent research indicates that its about the same as an amnio. I postef more on this on another topic. Don't worry, u will get through this. It is scary right now because things r unclear.

U know I just realized u may be too far along for a cvs. So I would work with your doctor on scheduling the ammnio quickly. I think they do that at 4 months.

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Offline Narendra

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Heena,

Check this out - http://www.bcchildrens.ca/NR/rdonlyres/CDC8350B-01D5-4727-AFA6-DAFACC2CAC25/42644/HemoglobinDbetathalassemia2.pdf

It says
Quote
IF ONE OF YOU HAS HEMOGLOBIN D TRAIT AND THE OTHER HAS BETA THALASSEMIA TRAIT, in every pregnancy there is a:
• 1 in 4 (25%) chance to have a baby with only the usual hemoglobin A. This is normal.
• 1 in 2 (50%) chance to have a baby with either hemoglobin D trait or beta thalassemia trait. This is harmless.
• 1 in 4 (25%) chance to have a baby with hemoglobin D/beta thalassemia. This too is
harmless.

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Offline Andy Battaglia

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Hi Heena,

I know it must raise some fears when you hear your child might inherit two thalassemia genes from the parents, but in the case of HbD and beta thal together, the result is usually a mild anemia, just like what is present in your first daughter. Your first daughter's blood reports reveal that she is also HbD/beta thal. These reports were posted at
http://www.thalassemiapatientsandfriends.com/index.php/topic,3998.msg39969.html#msg39969

Your first daughter's HbA is only 29% of the total. Her HbF is 6%. This shows that she inherited the beta thal gene from you and is a beta thal minor. She also received the HbD gene from her dad and this accounts for 61% of her hemoglobin. If the beta globin gene she inherited from you was normal, her HbA would be much higher and her Hb level would be higher than 10. You have to understand that the first daughter is the worst case that can come from your genes. Your new child could be the same as the first if it gets both genes. If it gets only one of these genes it will be similar to the mom or dad. If it gets neither gene, it will be normal with no anemia. One thing missing from your report is your own Hb level. What is it and have you had anemia throughout your life?
Andy

All we are saying is give thals a chance.

my HB LEVEL is 7.5 - 8.00 this i came to know only at the time of the pregnancy of  my first daughter and at that time only i came to know that i have MINOR THALASSAEMIA otherwise during my entire life i have never gone to any doctor for any medically problem due to annemia  and i never took any medicine or anything homemade/ayurvedic for annemia moreover after i came to know that i have minor thal even after that i am not eating/using anything even not the wheat grass and my health is perfectly all right even i am doing all my house work myself.

thanks   

 

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