• Welcome, Guest. Please login or register.
    May 07, 2021, 07:33:37 AM

  • Login with username, password and session length

Sajid's dove

Tell everyone they can now find this site by typing this into their browser:

thalpal.com

Click to visit us on Facebook


If you have any problems registering or signing in, please send an email to: andythalpal@yahoo.com
Please do not send questions about thalassemia to this address.


Administrators
Andy
Danielle

Thalassemia Patients and Friends and thalpal thalpal.com Ā© A. Battaglia 2021





55477 Posts in 5941 Topics by 6281 Members
Latest Member: Rawlscr1

This is Thalassemia Patients and Friends,
dedicated to its founder,
Lisa Cammilleri.
(1970-2004)
« previous next »
Pages: 1 Go Down Print
Author Topic: Alpha and Beta Traits Trying to get Pregnant  (Read 4415 times)
qwertyqwerty
New Member
*
Offline Offline

Posts: 2


« on: May 31, 2012, 05:47:12 PM »

Hi I was hoping for some advice with the following situation:

I have the Beta Thal Trait.  My wife has just bloode tested for possible Alpha traits, she is awaiting a re-test to confirm.

We are trying for a family.  I know with two Beta traits the chances are 75% on having a baby without the major trait.  The question is how does this affect someone who has the beta and alpha minor traits?

Thanks
Logged
Andy Battaglia
Administrator
Supreme Member
*****
Offline Offline

Location: In my heart, Maldives

Gender: Male
Posts: 8719


Will thal rule you or will you rule thal?


« Reply #1 on: May 31, 2012, 06:20:08 PM »

In most cases, there is no problem when alpha and beta minor mix. In fact, because both cause a reduction on the respective globins produced, it creates a better balance of globins and the patient is generally better off because there aren't unmatched globin chains as there normally is with minors. However, there is an exception. When an alpha minor has a triplicate mutation instead of the more common deletions, too much alpha globin is produced and cause cause an intermedia like condition when mixed with a beta mutation. This is more rare, but if alpha trait is diagnosed, the triplicated alpha gene needs to be ruled out, so DNA testing may be required.
Logged

Andy

All we are saying is give thals a chance.
qwertyqwerty
New Member
*
Offline Offline

Posts: 2


« Reply #2 on: May 31, 2012, 06:51:08 PM »

Hi Andy thanks for the quick reply.   That was the answer I was hoping for. Are there any symptoms for the triplicate mutation as my wife has never shown any.  Also is it possible to have beta and alpha minor.  I was diagnosed with beta back in 1993, just worried that as alpha is difficult to detect I could also have that?  Thanks,
Logged
Andy Battaglia
Administrator
Supreme Member
*****
Offline Offline

Location: In my heart, Maldives

Gender: Male
Posts: 8719


Will thal rule you or will you rule thal?


« Reply #3 on: May 31, 2012, 07:01:21 PM »

There may be some health issues from the triplicated gene, but not necessarily so. Yes, alpha and beta can co-exist because they affect two different genes on different chromosomes. Alpha trait is not easy to diagnose, so DNA testing is usually required. I highly recommend having the tests done for both so you can be sure there is no possibility of thal major children.
Logged

Andy

All we are saying is give thals a chance.
Pages: 1 Go Up Print 
« previous next »
Jump to:  

Powered by MySQL Powered by PHP Powered by SMF 1.1.21 | SMF © 2015, Simple Machines Valid XHTML 1.0! Valid CSS!