BMT or stem cell transplant

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Offline ama

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BMT or stem cell transplant
« on: July 15, 2013, 04:19:07 AM »
What is the difference between stem cell transplant and bone marrow transplant?

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Offline EugenioLaMesa

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Re: BMT or stem cell transplant
« Reply #1 on: August 17, 2013, 07:38:38 AM »
    I've noticed that there is often some confusion about this topic. Bone Marrow Transplant uses stem cells, and in many scientific papers on BMT have the words "stem cells" in the title:

    - Hematopoietic stem cell transplantation in thalassemia and sickle cell anemia
    - T cell-depleted hla-haploidentical stem cell transplantation in thalassemia young patients
    - Progress in hematopoietic stem cell transplantationas allogeneic cellular gene therapy in thalassemia [/li]

You can find a list of other papers in the Cure Thalassemia FAQ page:
www.curethalassemia.org/faq/

Maybe for "stem cells" you meant "cord blood"?
« Last Edit: August 20, 2013, 07:06:02 AM by EugenioLaMesa »
Eugenio La Mesa
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Re: BMT or stem cell transplant
« Reply #2 on: August 17, 2013, 01:37:34 PM »
In plain English, Bone Marrow Transplant (BMT) and Stem Cell Transplant (STM) are not same.

BMT is a total replacement of the patient bone marrow with the matched bone marrow of the donor. (This process is much riskier than SMT).

SMT uses the technique to correct the default genes in the patient bone marrow without any donor intervention.

Regards.

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Offline EugenioLaMesa

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Re: BMT or stem cell transplant
« Reply #3 on: August 20, 2013, 01:18:06 PM »
In plain English, Bone Marrow Transplant (BMT) and Stem Cell Transplant (STM) are not same.

BMT is a total replacement of the patient bone marrow with the matched bone marrow of the donor. (This process is much riskier than SMT).

SMT uses the technique to correct the default genes in the patient bone marrow without any donor intervention.


Thanks for your reply. I've double checked my previous answer with Dr. Pietro Sodani (Cure Thalassemia scientific coordinator, who has done more than 400 BMT) and he confirms that what I've written is correct. He says that you are probably talking about "stem cell gene therapy", while we do "stem cell transplantation" which is the "BMT".

This thread confirms me that there is some confusion on this topic, and we often receive questions from the Cure Thalassemia website of parents who ask "stem cell" vs "BMT" and we ask them to better clarify, they then explain that they mean "cord blood" vs "BMT", and that's why I wrote about cord blood.
Eugenio La Mesa
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Live without Thalassemia major - No more transfusions
Become our fan on Facebook: http://fb.com/CureThalassemia

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Offline Andy Battaglia

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Re: BMT or stem cell transplant
« Reply #4 on: August 21, 2013, 02:04:30 AM »
Yes, our friend Khalifa's son had both. His BMT failed but later on, stem cells were collected from the same donor's (the boy's sister) blood, and used for the stem cell transplant. Stem cells transplants are easier on the donor. Dr's Lucarelli and Sodani were the doctors that performed the procedure.
Andy

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