Male fertility

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Male fertility
« on: November 23, 2017, 03:24:23 PM »
Pediatr Res. 2017 Nov 22. doi: 10.1038/pr.2017.296. [Epub ahead of print]
Effect of iron overload on impaired fertility in male patients with transfusion-dependent beta-thalassemia.
Chen MJ1,2, Peng SF3, Lu MY4, Yang YL4,5, Jou ST4, Chang HH4, Chen SU1, Lin DT4,5, Lin KH4.
Author information
Abstract
BACKGROUND:
To investigate the fertility of male patients with transfusion-dependent beta-thalassemia, and use MRI as a novel method to assess the iron overload status of testis in such patients.
METHODS:
Twenty-one male patients with transfusion-dependent beta-thalassemia and 5 normal male controls enrolled in this study. Hormonal profiles, iron levels, MRI testicular dimension, MRI T2 values, parameters for sperm quality, sperm DNA fragmentation (SDF) of participants were measured.
RESULTS:
The MRI T2 values of the testis were significantly lower in transfusion-dependent beta-thalassemia patients than normal controls (P=0.027) and correlated to serum ferritin levels in all enrolled subjects (R square=0.258, P=0.008). There were significantly lower sperm concentrations (P=0.037), a lower percentage of sperm with normal morphology (P=0.001), and a higher percentage of SDF (P=0.009) in transfusion-dependent beta-thalassemia patients without hypogonadotropic hypogonadism and with spontaneous spermatogenesis compare to normal controls. The percentage of SDF was significantly correlated with serum ferritin levels in transfusion-dependent beta-thalassemia male patients with spontaneous spermatogenesis (R square=0.48, P=0.009).
CONCLUSION:
Our study is the first demonstration of iron deposition in the testis of patients with transfusion-dependent beta-thalassemia based on imaging and such findings might explain the high prevalence of impaired fertility in above patients with normal pituitary function.Pediatric Research accepted article preview online, 22 November 2017. doi:10.1038/pr.2017.296.
PMID: 29166371 DOI: 10.1038/pr.2017.296

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Offline Andy Battaglia

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Re: Male fertility
« Reply #1 on: November 23, 2017, 08:57:28 PM »
This has been observed for decades. Glad to see they finally got around to proving it.
Andy

All we are saying is give thals a chance.

 

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