COVID-19, is iron overload a relief?

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Offline jay

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COVID-19, is iron overload a relief?
« on: April 02, 2020, 03:13:28 PM »
Hello All,

It has been long since I was here. Miss you.
I came to see if someone has already raised this up and check for information and guidance.

It looks from initial studies (non-peer reviewed?) that SARS-CoV-2 molecule has some affinity towards heme.
Suggestions of hypoxia before lung failure due to knocking off iron from heme by the Virus.

I am not able to comprehend if that’s a relief OR a concern.
Jay has very good ferritin numbers ~300. We make on/off decision at around 400 desferal+ferriprox(liquid) [It’s not the dosage its the continuity]

Would it be recommended to stop chelation for adequately chelated thal at least for a while now. Does it make sense to think virus molecule will react with free iron.
What about elderly thal-minor, should transfusion be considered well within time after hospitalization because of COVID-19.

There is observation suggesting anemia is a factor in loss form this disease but is that really related to heme vs the virus.
Trials are going on all over for Hydroxychloroquine. Hydroxychloroquine-Malaria, Maleria-Thal is there any actual relation or is this effects of watching house md and the knick ..

References:
https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin/11938173
https://twitter.com/davidasinclair/status/1238972087395659778?s=19

Stay Home, stay safe and keep homes adequately humid (40-60).

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Offline jay

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Re: COVID-19, is iron overload a relief?
« Reply #1 on: April 02, 2020, 07:52:34 PM »
EMedTox has raised n number of questions.
https://twitter.com/emedtox?s=09

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Offline jay

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Re: COVID-19, is iron overload a relief?
« Reply #2 on: April 02, 2020, 08:32:02 PM »
I am pressing a panic button here, the information is growing on me very fast.

https://www.sicklecellsociety.org/coronavirus-and-scd/

Shielding! Extremely vulnerable group!! This is full blown alarm!!!

Take care buddies.

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Offline jay

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Re: COVID-19
« Reply #3 on: April 02, 2020, 08:58:29 PM »

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Offline Andy Battaglia

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Re: COVID-19, is iron overload a relief?
« Reply #4 on: April 22, 2020, 06:04:09 PM »
My interpretation of the study you mentioned would show this is less of a threat to thals, because the higher the Hb, the more likely one is to have serious consequences from Covid. Thals, with their lower Hb would be less affected, if that study's results are correct. Most other "studies" I have seen on what Covid does have been guess work.
Andy

All we are saying is give thals a chance.

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Offline IF

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Re: COVID-19, is iron overload a relief?
« Reply #5 on: July 22, 2020, 04:05:12 PM »
I have tularemia and also a health care worker. I had questions regarding how it will effect thal. I had covid on Easter weekend  and the test came back positive. It took me awhile to feel normal.  I did have all the symptoms. I was able to bring my O2 sat up in the consecutive days. I just want to know if there will be any problems down the road.

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Offline Andy Battaglia

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Re: COVID-19, is iron overload a relief?
« Reply #6 on: July 26, 2020, 10:50:35 PM »
IF,

I don't know if tularemia would affect thal, but if antibiotics are used to treat it, it's best to avoid any that contain sulfur, as sulfur can cause a drop in hemoglobin in many thals.
Andy

All we are saying is give thals a chance.

 

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