Pyruvate Kinase Activation

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Pyruvate Kinase Activation
« on: March 15, 2022, 07:02:59 PM »
Would this give credence to the theory of iron, before, the manifestation of Thalassemia?
Since iron inhibits pyruvate kinase?

The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model
https://pubmed.ncbi.nlm.nih.gov/33822774/


Iron-Dependent Oxidative Inactivation with Affinity Cleavage of Pyruvate Kinase.
https://link.springer.com/article/10.1007/s12011-009-8317-x

Re: Pyruvate Kinase Activation
« Reply #1 on: March 20, 2022, 07:22:26 PM »
This looks interesting. Is this treatment in the market now ?

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Offline Andy Battaglia

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Re: Pyruvate Kinase Activation
« Reply #2 on: March 23, 2022, 04:55:57 AM »
It was just approved in the US in February, 2022.
http://drugapprovalsint.com/mitapivat/

Quote
On February 17, 2022, the FDA approved mitapivat as the first disease-modifying treatment for hemolytic anemia in adults with pyruvate kinase (PK) deficiency, a rare, inherited disorder leading to lifelong hemolytic anemia.6 Mitapivat has also been investigated in other hereditary red blood cell disorders associated with hemolytic anemia, such as sickle cell disease and alpha- and beta-thalassemia.1
Andy

All we are saying is give thals a chance.

 

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