Bappy, it's a while since I've used s/c desferal but have you tried hot or cold compresses after the infusion has finished. I used to rotate injection sites from abdomen (left then right side), arms and thighs to give each site a good rest. I found the itchiness the worst part (and the lumps, oh I feel your pain). Am sure you can also mix hydrocortisone with the desferal for high dosages to reduce the irratation, but you would need to check this with your doctor or pharmacist. How much water do you mix the desferal with? I used balloon infusors as a teenager and they were mixed 48mls given over 48hours, the volume of the drug was awful and caused me lots of skin irritations. I much preferred the 10ml syringe pump method. Hope you get it sorted soon.