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iron overload

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shaista:
Hi,my son has major thallasaemia.He is 14 and his weight is 25kg.I want todo combine therapy of ASunra and Ferriprox as his ferritin 1s 5500.uptil now he was taking 500mg of ferripro in the morning and 500mg in the evening.Plz guide me abt the dosage of both Asunra and ferripro. He also took 500mg of Asunra a day for almost an year but even that didnt work so i decided to do combine therapy.

Andy Battaglia:
Hi shaista,

The current dose of Ferriprox is too low. The normal dosage is 75 mg/kg, so at his weight, the dose would be 1875 mg daily. I think the reason chelators are not working is the dosage is not high enough. The combination of Ferriprox and Exjade (Asunra) is not approved anywhere that I know of, so there is no suggested doses of the two drugs. Can you tell me what his dose of Asunra was daily?

shaista:
Thanks for reply.I am giving Mohib 600mg of Asunra two days aweek and 15oomg of kelfer 5days a week.I started this combine therapy few days ago.Shall i stop it.

Andy Battaglia:
I would say that if you are doing this with the understanding that all testing for side effects is faithfully done each month, then you can try it. Both Ferriprox and Exjade require regular testing. For Ferriprox, white cell counts must be closely observed. With Exjade (Asunra, Desirox) creatinine levels and ALTs should be regularly monitored.

shaista:
thanks for concern.I monitor Mohib closely by doing all the required tests and so far he is doing well.I will post all the results when his tests will be condcted after 15 days.You didnt tell me that what should be the dose of Asunra and kelfer in combine therapy.Shall i give Mohib 2000mg of kelfer aday for 5days aweek and asunra 600mg aday for 2days.Is this ok.Moreover I am daily giving him 400mg of Calcium 500mg of Vitamin C,200mg of Vitamin E and 20mg of Folic acid. He also takes wheatgrass.Plz tell me if he needs someother supplement .or these are ok.

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