Discussion Forums > General Chatter
iron overload
Andy Battaglia:
Since there are no recommendations regarding this combination and very little research into the combination, I have a difficult time advising you. Have you talked to your doctor about this?
shaista:
unfortunately I donot know any heamatologist in Peshawar.I do all the medication either by myself or sometimes i get advice from Dr. Farrukhshah of whittington hospital inUK.I read about combination therapy at this forum so I thougt it might proved helpful for Mohib As well.
Andy Battaglia:
OK, all I can do then is tell you the proper dosage of each drug for his weight.
25 kg x 75 mg + 1875 mg Ferriprox daily. Maximun tolerable dose is 2500/day. 2000 mg daily would be appropriate considering his ferritin level. If this is the only chelator used, he should take this dose split for 3 times daily, 7 days a week.
25 kg x 30 mg = 750 mg Asunra daily. 800 would be fine at his ferritin level. So as not to interfere with his appetite, I would suggest splitting the dose into two and taking half in morning and half in evening. His low weight tells me that he needs help with his diet so that he is getting enough calories and nutrients.
Work out a suitable routine for his chelation. Make sure he takes one or the other every day. I would also suggest raising the folic acid level to 200 mcg daily. (I am sure he is not taking 20 mg because that is a huge dose. If I am wrong, correct me. Folic acid is usually found in mcg doses).
Getting his ferritin down now is essential as the iron load is interfering with his growth. Has he ever been on desferal?
Andy Battaglia:
Shaista,
The one thing I want you to remember is that we are here to help you. I want you to take advantage of this and continue to ask our help. I want your son to do better than he has in the past. Time is urgent because he is at an age where development is hindered by iron. Let us help you work to turn things around for your son.
Sharmin:
Shaista,
I completely agree with Andy. These are critical years in your son's growth and development. Decreasing his iron now will allow his pituitary to work efficiently and allow him to grow and develop normally.
Please keep us updated about his progress. With combination chelation we were able to reduce my son's ferritin f2om 2800 to 700 in one year - it can decrease rapidly if you are compliant and on a good plan.
Best of luck!
Sharmin
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