Study Finds Antioxidant Deficiency Linked To Pulmonary Hypertension

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Offline Andy Battaglia

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Pulmonary Hypertension (PHT or PAH) is a major complication in thalassemia and a leading cause of death of thal majors. It has been linked to several causes and a new discovery may provide much insight into what is taking place and what can be done to help prevent PHT. I cannot over-emphasize the importance of antioxidants to thalassemics.

Study Finds Antioxidant Deficiency Linked To Pulmonary Hypertension
Main Category: Cardiovascular / Cardiology
Also Included In: Hypertension
Article Date: 24 Sep 2008 -

A recent study shows that a loss of antioxidants in the endothelial cells that line blood vessels in the lungs contributes to the loss of vasodilator effects and, ultimately, to the development of pulmonary hypertension. The findings appear in Clinical and Translational Science.

The study, led by Serpil Erzurum of the Cleveland Clinic, evaluated antioxidant activities in patients with idiopathic pulmonary arterial hypertension (IPAH), a fatal disease characterized by progressive increase in pulmonary artery pressure and vascular resistance.

Erzurum's study found that the inactivation of these oxidants inside the cell is achieved mainly by the cell's own line of defense against oxidants. Additionally, the researchers determined that this process may contribute to low levels of nitric oxide, identified in IPAH and a fundamental component in the pathogenesis of pulmonary hypertension.

According to Dr. Erzurum, there is a potential long-term benefit to the care of patients with IPAH due to the study's findings. "Antioxidant augmentation in patients might be used to increase nitric oxide vasodilator effects, reduce pulmonary artery pressures and potentially improve clinical outcomes," she said.

To view the abstract for this article, please click here.

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Offline Manal

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Re: Study Finds Antioxidant Deficiency Linked To Pulmonary Hypertension
« Reply #1 on: October 16, 2008, 07:40:07 AM »
Thank you Andy, this will definety make everyone keen not to skip a dose of the antioxidant



Offline Annie

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Re: Study Finds Antioxidant Deficiency Linked To Pulmonary Hypertension
« Reply #2 on: October 16, 2008, 08:25:41 AM »
Thank you so much


Offline Ayesha

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Re: Study Finds Antioxidant Deficiency Linked To Pulmonary Hypertension
« Reply #3 on: October 16, 2008, 09:02:26 AM »
antioxidants are? sorry am dumb!


Offline nice friend

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Re: Study Finds Antioxidant Deficiency Linked To Pulmonary Hypertension
« Reply #4 on: October 16, 2008, 10:49:31 AM »
Antioxidant: A substance capable of protecting other substances from oxidation; some are made by the body to inhibit the destructive actions of chemicals called free radicals; some, such as vitamins C and E, are nutrients

i think i m guiding right ...

Antioxidant: Antioxidants are chemical substances that help protect against cell damage from free radicals. Well known antioxidants include vitamin A, vitamin C, vitamin E, carotenoids, and flavonoids.

please correct me if i m guiding wrong ....
@ Ayesha
if you mean to know about the list of antioxidents  .. then please let me know i will try to find that ....

note : olives and olive oil are also antioxidants soo  add olive oil in your meal's recipe instead of cooking oil that usualy used in homes ...

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Offline Zaini

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Re: Study Finds Antioxidant Deficiency Linked To Pulmonary Hypertension
« Reply #5 on: October 16, 2008, 02:24:41 PM »

Welcome to the dumb club  :rotfl i am the president :rotfl

Anyways what i get of antioxidants is that they secure your blood cells and organs from the damage done by free radicals,such as iron in your case.As thal majors have iron over load,iron is constantly present in their blood stream.

I hope i am right.



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