For some perspective on vitamin D dosage, I asked Dr Vichinsky about this because I am quite deficient in D (level of only 19), and requested some advice. Dr Vichinsky told me that with the thal patients, they are now administering 50,000 IU of D weekly, because the smaller doses aren't having much impact. Interestingly, this jibes with the advice that our member Bigg has given. I am now starting on this regimen. I hope it helps because with the winter months coming, I need to correct my situation or I will be quite the depressed person, literally, because low D does also cause depression.