Bisphosphonate

Dear All,
Lately I have some problem with the Osteoporosis. Therefore I am taking calcium and vitamin D combination pills.
My doctor recommended to start taking "bisphosphonate".
Any idea, experience with this ?
Thanks for your feedback.

Bye, Panos

Panos,

Bisphosphonates are a class of drugs used to rebuild bone mass that is lost to osteoporosis, which is common in thalassemics, especially as they age, regardless of supplementation with calcium and vitamin D and good chelation. (I do feel that more study should be done on the effect of large doses of vitamin D on improving bone mass). Some of these drugs are alendronate, pamidronate, and zoledronate, with zoledronate being the newest generation of the drugs and also shown to be the safest and most effective of these drugs that have been used with thalassemics. Do you know which drug the doctor has suggested?

hi andy

now i got the name...
it is called fosamax....
i start imediatli because my bones are very worst.....
did u know s about it?

Hi Panos,

Yes, Fosamax (alendronate sodium) is one of the oldest bone meds. Zoledronic acid is the 4th generation and newest of the bone meds. Many patients do well with Fosamax but some have side effects. See how you do with it but if you have any bad side effects, ask about Zoledronic acid. It is the most costly of the drugs so they try the others first, but it does have fewer reported side effects.

Good luck with Fosamax Panos 

I think one of our memebers Umair is also using it? Umair! correct me if i am wrong?

Zaini.

@ Panoz & Zaini ,
Hi Zaini ,
yeah, zaini You're right but i used to take this, not using , i used to take this medicine a little ago ... and then i had to stop this bcoze of my stomach that was poor to tolerate anything at that moment bcoze of pain-killers ( when i was on wheel chair almost 2 and half year ago )....

Good luck Panoz ,  i used to take this medicine along time ago ( almost 2 years ) its a good medicine ,and it was available in 70mg for once weekly and 10mg for daily on an empty stomach..... after taking this medicine you should avoid to go in bed , you can walk , Sit actively but not go to bed for next 30  minutes, it is most important thing that i want to mention ... it was working but that time bcoze of pain-killers i had a poor stomach ... its a super good medicine Salman ( Ayesha's bro )  is taking this tablet ( another drug with same formule to Fosamax ) , if i  not wrong .... Good luck buddy and have faith you will be all-right and then we'ill play foozbal+Soccer togather ....

Best Regards
Take Care
Umair

hi buddys

thx umair for replay...
oki i told my doc about ur thinking of forsamax....
but...we cant get the zoledronic here in germany...
so i became a naouter one called aktonel 35...
du u know this one andy?
i started the next WE....
                              panos

From http://www.actonel.com/global/Actonel_PIL.pdf

   ACTONEL may reverse bone loss by stopping more loss of bone and increasing bone
strength in most people who take it, even though they won’t be able to see or feel a
difference. ACTONEL helps lower the risk of breaking bones (fractures). Your healthcare
provider may measure the thickness (density) of your bones or do other tests to check your
progress.
Who should not take ACTONEL?
Do not take ACTONEL if you:

• have low blood calcium (hypocalcemia)
• cannot sit or stand up for 30 minutes
• have kidneys that work poorly
• have an allergy to ACTONEL. The active ingredient in ACTONEL is risedronate
sodium. (See the end of this leaflet for a list of all the ingredients in ACTONEL.)

The following instructions apply to all patients taking ACTONEL:
• Take ACTONEL exactly as prescribed by your healthcare provider.
• Take ACTONEL first thing in the morning before you eat or drink anything except plain
water.
• Take ACTONEL while you are sitting up or standing.
• Take ACTONEL with 6 to 8 ounces (about 1 cup) of plain water. Do not take it with
any other drink besides plain water.
• Swallow ACTONEL whole. Do not chew the tablet or keep it in your mouth to melt or
dissolve.
• After taking ACTONEL you must wait at least 30 minutes BEFORE:
• lying down. You may sit, stand, or do normal activities like read the newspaper
or take a walk.
• eating or drinking anything except plain water.
• taking vitamins, calcium, or antacids. Take vitamins, calcium, and antacids at a
different time of the day from when you take ACTONEL.

Zaini.

Panos,

That's another of the family of bisphosphonates. Fosamax was the first generation and Actonel is the second. These drugs work for many people but many others have significant side effects. If you do experience any severe bone or muscle pain, stop taking the drug and call your doctor.

http://www.actonel.com/

Important Safety Information for
ACTONEL® (risedronate sodium) tablets

You should not take ACTONEL if you are allergic to any of the ingredients, if you have low blood calcium (hypocalcemia), have kidneys that work poorly, or cannot stand or sit upright for 30 minutes.

Stop taking ACTONEL and tell your doctor right away if you experience difficult or painful swallowing, chest pain, or severe or continuing heartburn, as these may be signs of serious upper digestive problems. Follow dosing instructions carefully to lower the chance of these events occurring.

Side effects may include stomach pain, upset stomach, or back, muscle, bone or joint pain, sometimes severe. Contact your doctor for medical advice about side effects, or if you have questions about ACTONEL. Promptly tell your doctor if you develop dental problems; there have been rare reports of jaw problems.

I would like to see a study comparing the results using these drugs to a program of calcium, magnesium and mega doses of vitamin D. I think the main failing of calcium supplements has been not taking magnesium and adequate amounts of vitamin D. The vitamin D dosage that has been thought to be sufficient has turned out to be greatly deficient.

Bisphosphonates are "crystalization inhibitors".
Phytate found in your food is also a bisphosphonate.
These drugs they have developed for the treatment of osteoporosis are simple 'knockoffs' of the chaff of your grain.
Believe it or not ..

"Etidronate belongs to a class of medications called bisphosphonates"

Effect of Crystallization Inhibitors on Vascular Calcifications
Induced by Vitamin D : A Pilot Study in Sprague-Dawley Rats
Circulation journal : official journal of the Japanese Circulation
Society
Vol.71, No.7(20070620) pp. 1152-1156
Japanese Circulation Society ISSN:13469843
Bibliography
Abstract
Background
Pathological calcification in soft tissues (ie, ectopic calcification)
can have severe consequences.
Hydroxyapatite is the common mineral phase present in all tissue
calcifications.
In general, the development of tissue calcifications requires a pre-
existing injury as an inducer (heterogeneous nucleant), whereas
further progression requires the presence of other promoter factors
(such as hypercalcemia and/or hyperphosphatemia) and/or a
deficiency in calcification represser factors (crystallization inhibitors
and cellular defense mechanisms).
The present study investigated the capacity of etidronate (a
bisphosphonate used in osteoporosis treatment) and phytate
(a natural product) to inhibit vascular calcification in rats.
Methods and Results
Six male Sprague-Dawley rats in each of the 3 treatment groups
were subcutaneously injected with either a placebo (physiological serum
solution), etidronate (0.825μmol・kg^<-1>・day^<-1>) or phytate
(0.825μmol・kg^<-1>・day^<-1>) for 8 days.
Four days into this regimen, calcinosis was induced by subcutaneous
injections of 500,000 IU/kg vitamin D at Oh, 24h and 48h.
Ninety-six hours after the final vitamin D injection, the rats were
killed and aortas and their hearts were removed for histological and
calcium analyses.
The data showed that phytate-treated rats had lower levels of aortic
calcium than placebo-treated rats.
All groups had similar heart calcium levels.
Conclusions
The present study found that phytate acted as a vascular
calcification inhibitor.
Thus, the action of polyphosphates could be important in protecting
against vascular calcification.

Grases Felix 1 Sanchis Pilar 2 Perello Joan 3 Isern Bernat 4 Prieto
Rafel M. 5 Fernandez-Palomeque Carlos 6 Torres Jose J 7
1Laboratory of Renal Lithiasis Research, University Institute of
Health Sciences Research (IUNICS), University of Balearic Islands
2Laboratory of Renal Lithiasis Research, University Institute of
Health Sciences Research (IUNICS), University of Balearic Islands
3Laboratory of Renal Lithiasis Research, University Institute of
Health Sciences Research (IUNICS), University of Balearic Islands
4Laboratory of Renal Lithiasis Research, University Institute of
Health Sciences Research (IUNICS), University of Balearic Islands
5Laboratory of Renal Lithiasis Research, University Institute of
Health Sciences Research (IUNICS), University of Balearic Islands
6University Hospital Son Dureta 7University Hospital Son Dureta
Keyword Crystallization inhibitors Etidronate Phytate Vascular
calcification Vitamin D

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after a half year of taking bondronat

my bones get more "stabil".

i get it ones a month IV.

                panos