Discussion Forums > Thalassemia Major

Slow rate transfusion and warm antibody

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Sharmin:
Thank you for your prayers Maha and Zaini  :hugfriend
Maha, we have at times done post tx hg - but the doctor has not done it lately.  Thank you for the reminder, I will mention it to him today. 

Andy, with the slow rate, lower volume tx - should we notice the lower antibody activity (rapid hemolysis) with each individual tx - or are we looking for a long term benefit - after a few transfusions a reduction in the rate of hemolysis?    My guess was that we are looking for a change with individual tx - because that particular tx is causing less shock to the body - hence triggering less antibody activity. 

Thanks again Andy, I will update you all after our tx today - sending my best to all of you  :hugfriend :hugfriend

Sharmin

Andy Battaglia:
Sharmin,

Yes, the hope is that a slower transfusion rate will cause less hemolysis. And with a lower amount of blood being transfused, the HB will drop more quickly just because the same volume of blood isn't taken. Weekly transfusions are often the answer until the antibody problem is under control. Prednisone shock may be the answer, but I would wait and talk to Dr Vichinsky before taking that action.

Sharmin:
Thanks Andy,

Today they give him 1 bag - less than 15cc/kg and we will go in for a second bag on Friday.  We then plan on going in weekly until his hg is high enough with the one bag to tx every two weeks.  We are continuing with the 10mg alternate days of prednisone until we speak with Dr. Vichinsky.

Our hope is to get on a better treatment plan after our visit in Oakland, also to bring back valuable information for other patients.  I hope what we learn will also help Rositka and the family in Greece.  There are ways to deal with this issue we just have to learn how it can be managed. 

Thank you everyone for your wishes and thank you Andy for the wealth of information and insight.

Sharmin

Kathy11:
HI Sharmin.

Thinking of you at this hard time. chin up, hopefully your child will get  better soon
To you :flowers :flowers :flowers :flowers :flowers :flowers :flowers :flowers
Take care Kathy

Sharmin:
Thank you Kathy,  your wishes warm my heart at this time:)
 :love :love :love

I hope that you also are well:)

Sharmin

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